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vascular endothelial growth factor C
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor D. [provided by RefSeq]
Diseases
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|
||
|---|---|---|---|
| Whipple's disease |
100
|
||
| Crush injury, multip… |
79
|
||
| Age-associated memor… |
78
|
||
| Osteosarcoma of bone |
77
|
||
| High fat diet |
75
|
||
| Spinal muscular atro… |
75
|
Gene perturbations
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|
||
|---|---|---|---|
| CDX2 gene |
100
|
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| POU5F1 gene |
97
|
||
| RUNX1T1 gene |
94
|
||
| HBA1 gene |
92
|
||
| HBB gene |
92
|
||
| LASP1 gene |
92
|
Compounds
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|
||
|---|---|---|---|
| Aceclofenac |
100
|
||
| Gelatin |
93
|
||
| Lorazepam |
86
|
||
| Pemoline |
81
|
||
| Benzothiazide |
81
|
||
| Thiabendazole |
77
|
 Individual Studies |
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|---|---|
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Mus musculus
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RNA Expression
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Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism.
Authors: Agnes Machnik, Wolfgang Neuhofer, Jonathan Jantsch, Anke Dahlmann, Tuomas Tammela, Katharina Machura, Joon-Keun Park, Franz-Xaver Beck, Dominik N Müller, Wolfgang Derer,…
Nature medicine 2009 May -
High VEGFC expression is associated with unique gene expression profiles and predicts adverse prognosis in pediatric and adult acute myeloid leukemia.
Authors: Hendrik J M de Jonge, Peter J M Valk, Nic J G M Veeger, Arja Ter Elst, Monique L den Boer, Jacqueline Cloos, Valérie de Haas, Marry M van den Heuvel-Eibrink, Gertjan J L Kaspers, Christian M Zwaan,…
Blood 2010 Jun 3
Thought leaders and organizations working on research involving VEGFC.
- M.D. Anderson Cancer Center
- North Central Cancer Treatment Group
- Massachusetts General Hospital and Harvard Medical School
- Haartman Institute and Helsinki University Central Hospital
- Helsinki University Central Hospital
- National Taiwan University
- Mayo Clinic Cancer Center
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Fibrin Melanoma Axillary Node Study in Patients With Melanoma
conditions: Melanoma
interventions: Fibrin Sealant
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Evaluating the Use of Fibrin Tissue Adhesive in Melanoma Patients
conditions: Melanoma
interventions: Fibrin Sealant
