RESEARCH
PUBLICATIONS
NEXTBIO COMMUNITY
Videosnew
FAQnew
vav 3 guanine nucleotide exchange factor
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq]
Diseases
|
|
||
|---|---|---|---|
| Undifferentiated car… |
100
|
||
| Melanocytic nevus |
90
|
||
| Melanocytic tumor of… |
90
|
||
| Breast lobule hyperp… |
86
|
||
| Acute gastric mucosa… |
85
|
||
| Adenocarcinoma of la… |
84
|
Gene perturbations
|
|
||
|---|---|---|---|
| MIRN98 gene |
100
|
||
| DHX36 gene |
88
|
||
| AVP gene |
86
|
||
| MAPK14 gene |
85
|
||
| ras gene |
83
|
||
| PTK2 gene |
77
|
Compounds
|
|
||
|---|---|---|---|
| 4'-epidaunomycin |
100
|
||
| Fusidic Acid |
91
|
||
| Dactinomycin |
89
|
||
| Luteolin |
88
|
||
| Interferon gamma (1-… |
87
|
||
| Pepstatin |
85
|
 Individual Studies |
|
|---|---|
|
|
Homo sapiens
|
RNA Expression
-
Vav3 proto-oncogene deficiency leads to sympathetic hyperactivity and cardiovascular dysfunction.
Authors: Vincent Sauzeau, María A Sevilla, Juan V Rivas-Elena, Enrique de Alava, María J Montero, José M López-Novoa, Xosé R Bustelo
Nature medicine 2006 Jul -
Vav3 regulates osteoclast function and bone mass.
Authors: Roberta Faccio, Steven L Teitelbaum, Keiko Fujikawa, Jean Chappel, Alberta Zallone, Victor L Tybulewicz, F Patrick Ross, Wojciech Swat
Nature medicine 2005 Mar
Thought leaders and organizations working on research involving VAV3.
- Washington University School of Medicine
- University of Salamanca
- University of Cincinnati College of Medicine
- Harvard Medical School
- University of Chicago
