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Description: Alfuzosin (INN, provided as the hydrochloride salt) is an alpha-adrenergic blocker used to treat benign prostatic hyperplasia (BPH). It works by relaxing the muscles in the prostate and bladder neck, making it easier to urinate. [Wikipedia]
Drug Type: Small Molecule; Approved; Investigational
Pharmacology: Alfuzosin is an alpha-adrenergic blocking agent used to treat hypertension and benign prostatic hyperplasia. Accordingly, alfuzosin is a selective inhibitor of the alpha1 subtype of alpha adrenergic receptors. In the human prostate, alfuzosin antagonizes phenylephrine (alpha1 agonist)-induced contractions, in vitro, and binds with high affinity to the alpha1c adrenoceptor, which is thought to be the predominant functional type in the prostate. Studies in normal human subjects have shown that alfuzosin competitively antagonized the pressor effects of phenylephrine (an alpha1 agonist) and the systolic pressor effect of norepinephrine. The antihypertensive effect of alfuzosin results from a decrease in systemic vascular resistance and the parent compound alfuzosin is primarily responsible for the antihypertensive activity.
Mechanism of Action: Alfuzosin acts by inhibiting the postsynaptic alpha(1)-adrenoceptors on vascular smooth muscle. This inhibits the vasoconstrictor effect of circulating and locally released catecholamines (epinephrine and norepinephrine), resulting in peripheral vasodilation.
Indication: For the treatment of the signs and symptoms of benign prostatic hyperplasia.
Half Life: 10 hours
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Data Correlations | 2 studies

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Genes category icon Genes
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ADRA1A 100 100
CD69 93 93
PIP5K1A 90 90
CHST3 90 90
MMP14 89 89
TRIM38 87 87
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Biogroups category icon Biogroups
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Biotin Metabolism 100 100
Nucleosome assembly protein (NAP) 95 95
Sulphotransferase 95 95
Butyrophylin-like 94 94
IL-18 Pathway 94 94
Cell division/GTP binding protein 94 94
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Individual Studies

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    Organization: Department of Computing Science, Univers…

  • Broad Connectivity Map (CMAP 2.0) compound database

    Homo sapiens Homo sapiens | RNA Expression   RNA Expression

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Associated Researchers

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Thought leaders and organizations working on research involving Uroxatral.

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  • Mark Emberton
  • ALF-ONE Study Group
  • Guy Vallancien
  • Mostafa Elhilali
  • Haim Matzkin
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  • Sanofi-Aventis
  • Samsung Medical Center
  • University of Minnesota
  • National Institute of Diabetes and Digestive and Kidney Diseases (NIDD…
  • Ferring Pharmaceuticals
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  • Tulane University Health Sciences Center
  • University of Amsterdam
  • Queen's University
  • Yonsei University Health System
  • University of California, San Francisco

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