Urethane - NextBio

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Search Term: Urethane (treatment)

Overview

Description:	Ethyl carbamate (also known as urethan and urethane), formerly marketed as an inactive ingredient in Profenil injection, was determined to be carcinogenic and was removed from the Canadian, US, and UK markets in 1963.
Drug Type:	Small Molecule; Withdrawn

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Data Correlations | 4 studies

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Genes

Score

CDKN1A

100

LYG1

H2-T23

Serpina3h

PHLDA3

KRT78

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Biogroups

Score

Calcineurin Pathway

100

Rac CYCD Pathway

Phospholipase A2, active site

P53 Signaling Pathway

Peptidase M10A and M12B, matrixin a…

Cell Cycle

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Individual Studies
Drug target sets for approved compounds Homo sapiens \| Therapeutic The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information. Authors: David S Wishart, Craig Knox, An Chi Guo et al. Organization: Department of Computing Science, Univers…	Mouse bronchoalveolar cells treated with urethane and normal lung tissue at different ages Mus musculus \| RNA Expression Expression data from AJ mouse control lung tissue and expression data of bronchoalveolar lavage cells from control or urethane treated AJ mice. Organization: UCHSC Medicine/Pulmonary Stearman 4200 E…

Individual Studies

Drug target sets for approved compounds

Homo sapiens | Therapeutic

The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

Authors: David S Wishart, Craig Knox, An Chi Guo et al.

Organization: Department of Computing Science, Univers…

Mouse bronchoalveolar cells treated with urethane and normal lung tissue at different ages

Mus musculus | RNA Expression

Expression data from AJ mouse control lung tissue and expression data of bronchoalveolar lavage cells from control or urethane treated AJ mice.

Organization: UCHSC Medicine/Pulmonary Stearman 4200 E…

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Literature | 46,370 results

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Overexpression of Sprouty 2 in mouse lung epithelium inhibits urethane-induced tumorigenesis.

Authors: George Minowada, York E Miller
American journal of respiratory cell and molecular biology 2009 Jan
Glutathione transferase pi plays a critical role in the development of lung carcinogenesis following exposure to tobacco-related carcinogens and urethane.

Authors: Kenneth J Ritchie, Colin J Henderson, Xiu Jun Wang, Olga Vassieva, Dianne Carrie, Peter B Farmer, Margaret Gaskell, Kevin Park, C Roland Wolf
Cancer research 2007 Oct 1

Associated Researchers

Thought leaders and organizations working on research involving Urethane.

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Authors

Jun Li
Xian Jun Loh
S-Ja Tseng
Laszlo Zaborszky
Shiue-Cheng Tang

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Clinical Trials Sponsors

University of Chicago
University of Iowa
Zimmer, Inc.
Maastricht University Medical Center
Interventional Spine, Inc.

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Organizations

Eötvös Loránd University
Case Western Reserve University
National Tsing Hua University
Japan Science and Technology Agency
National University of Singapore

Clinical Trials | 6 trials

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Comparison of Two Methods of Negative Pressure Wound Therapy

conditions: Acute Wounds From Trauma ; Dehiscence or Surgical Complications

interventions: Gauze suction (G-SUC) ; Vacuum Assisted Closure Device (VAC)
Outcome Evaluation of Ceramic Crowns Using Two Different Dental Cements

conditions: Sensitivity to Dental Cements ; Dental Crowns ; Dental Three-Unit Bridges

interventions: Full ceramic crowns or 3-unit fixed partial dentures.

News | 8 stories

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Active Implants Announces CE Class III Medical Device Approval
Medical News Today. - September 02, 2009
Researchers Spawn a New Breed of Robotic Fish
Scientific American.com.

Community

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NextBio Users | 1 person

Sudershan Gondi
POSTDOCTORAL FELLOW

southwestern medical center at dallas

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