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ubiquitin-conjugating enzyme E2T (putative)
The covalent conjugation of ubiquitin to proteins regulates diverse cellular pathways and proteins. Ubiquitin is transferred to a target protein through a concerted action of a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), such as UBE2T, and a ubiquitin ligase (E3) (Machida et al., 2006 [PubMed 16916645]).[supplied by OMIM]
Normal tissues
|
|
||
|---|---|---|---|
| Zygote |
100
|
||
| Femur |
85
|
||
| Oocyte |
81
|
||
| Viscerocranial mucos… |
70
|
||
| Mesenteric lymph nod… |
69
|
||
| Uterine tube |
69
|
Compounds
|
|
||
|---|---|---|---|
| Lysophosphatidic Aci… |
100
|
||
| Copper(2+) Acrylate |
96
|
||
| SID 7980107 |
87
|
||
| N-formylmethionine L… |
87
|
||
| Sphingosine |
85
|
||
| Prostaglandins E |
81
|
 Individual Studies |
|
|---|---|
|
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Mus musculus
|
RNA Expression
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UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation.
Authors: Yuichi J Machida, Yuka Machida, Yuefeng Chen, Allan M Gurtan, Gary M Kupfer, Alan D D'Andrea, Anindya Dutta
Molecular cell 2006 Aug -
Mechanistic insight into site-restricted monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI.
Authors: Arno F Alpi, Paul E Pace, M Madan Babu, Ketan J Patel
Molecular cell 2008 Dec 26
Thought leaders and organizations working on research involving UBE2T.
- Yale University
- Laboratory of Molecular Biology
- Howard Hughes Medical Institute and Division of Biology
- University of Tokyo
- University of Oklahoma Health Sciences Center
