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ubiquitin-conjugating enzyme E2R 2

Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation. [provided by RefSeq]

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Data Correlations | 1,053 studies

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Tissues category icon Normal tissues
Score Help
Mucosa of mouth 100 100
Esophagus 95 95
Nipple 89 89
Hemisphere of cerebe… 81 81
Superior vena cava 80 80
Cecum 79 79
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Compounds category icon Compounds
Score Help
Grenz Rays 100 100
Nsc720094 90 90
Dapt 85 85
Zymolyase 75 75
Transforming Growth … 75 75
Bpde 72 72
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Diseases category icon Diseases
Score Help
Scarlet fever 100 100
Non-alcoholic fatty … 92 92
Acromegaly 92 92
Craniorachischisis 90 90
Leprosy reversal rea… 90 90
Borderline tuberculo… 90 90
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Individual Studies

  • Amplification of whole tumor genomes from limited sources of DNA

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    Sufficient quantity of genomic DNA can be a bottleneck in genome-wide analysis of clinical tissue samples. DNA polymerase Phi29 can be used for the random-primed amplification of whole genomes, although the amplification may introduce bias in gene dosage. We have performed a detailed investigation o…

    Organization: Stanford Microarray Database (SMD) Stanf…

  • Human malignant melanoma cell lines exposed to carbon ions or X-rays

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    n this study, we examined the cytotoxic effects of C-ions on 6 human malignant melanoma cell lines, and gene expression profiles and cell cycle progr ession were also examined to reveal the mechanism of the therapeutic effectiveness of C-ions

    Authors: Matsumoto Yoshitaka, Iwakawa Mayumi, Furusawa Yoshiya et al.

    Organization: National Institute of Radiological Scien…
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Associated Researchers

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Thought leaders and organizations working on research involving UBE2R2.

View All Author iconAuthors
  • Raymond J Deshaies
  • Gary Kleiger
  • Kim Nasmyth
  • K Matthew Scaglione
  • Dorota Skowyra
View All Affiliations icon Organizations
  • Howard Hughes Medical Institute
  • National Cancer Institute
  • University of Toronto
  • Howard Hughes Medical Institute and the Division of Biology
  • Indiana University

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