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Description: An anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. It has been shown to reduce bone resorption in periodontal disease by inhibiting carbonic anhydrase. [PubChem]
Drug Type: Small Molecule; Approved
Pharmacology: Flurbiprofen, a nonsteroidal antiinflammatory drug (NSAID) of the propionic acid class, is used for the relief of pain and inflammation associated with rheumatoid arthritis and osteoarthritis and for the inhibition of intraoperative miosis. Flurbiprofen exhibits antiinflammatory, analgesic, and antipyretic activities.
Mechanism of Action: The antiinflammatory effect of flurbiprofen may result from the reversible inhibition of cyclooxygenase, causing the peripheral inhibition of prostaglandin synthesis. Flurbiprofen also inhibits the migration of leukocytes into sites of inflammation and prevents the formation of thromboxane A2, an aggregating agent, by the platelets.
Indication: Flurbiprofen tablets are indicated for the acute or long-term treatment of the signs and symptoms of rheumatoid arthritis and osteorarthritis.
Half Life: 4.7-5.7 hours
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Data Correlations | 2 studies

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Genes category icon Genes
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PTGS2 100 100
PTGS1 100 100
FAIM3 100 100
POLH 95 95
SLC35D1 93 93
ROCK1 93 93
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Biogroups category icon Biogroups
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chr14q 100 100
Platelet Activation Signaling Pathw… 99 99
Activation of cAMP-dependent Protei… 96 96
chr1p32 96 96
chr2q35 95 95
chr5q15 95 95
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Individual Studies

  • Drug target sets for approved compounds

    Homo sapiens Homo sapiens | Therapeutic   Therapeutic

    The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

    Authors: David S Wishart, Craig Knox, An Chi Guo et al.

    Organization: Department of Computing Science, Univers…

  • Broad Connectivity Map (CMAP 2.0) compound database

    Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    A reference collection of genome-wide transcriptional expression data from cultured human cells treated with bioactive small molecules that enable the discovery of functional connections between drugs, genes and diseases through the transitory feature of common gene-expression changes.

    Authors: Lamb J

    Organization: Broad Institute Seven Cambridge Center C…
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Associated Researchers

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Thought leaders and organizations working on research involving Tarenflurbil.

View All Author iconAuthors
  • Yoshitaka Fujii
  • Bruno P Imbimbo
  • M L García
  • Fatima Khwaja
  • E Vega
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • National Institute of Dental and Craniofacial Research (NIDCR)
  • GlaxoSmithKline
  • Nanjing Medical University
  • Sanofi-Aventis
  • Teikoku Pharma USA
View All Affiliations icon Organizations
  • Georgetown University Medical Center
  • Toho University School of Medicine
  • University of Illinois at Chicago
  • National University of Singapore
  • University of Oxford

Clinical Trials | 23 trials

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