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tyrosinase-related protein 1

This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. [provided by RefSeq]

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Data Correlations | 665 studies

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Tissues category icon Normal tissues
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Vulva 100 100
Nipple 93 93
Penis 90 90
Mucosa of mouth 77 77
Retina 70 70
Pylorus 67 67
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Compounds category icon Compounds
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U 0126 100 100
Benzo[e]pyrene 93 93
Uridine 5'-(pentahyd… 86 86
Olive Oil (tn) 82 82
Polyamide Ii 76 76
Genistein 69 69
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Diseases category icon Diseases
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Pigment dispersion s… 100 100
Albinism 99 99
Disease due to Papil… 94 94
Lepromatous leprosy 85 85
Leprosy reversal rea… 80 80
Complete trisomy 18 … 79 79
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Individual Studies

  • Mouse Phenotypes - Disorder of anterior segment of eye

    score: 100100 | Mus musculus Mus musculus | Mutations/Phenotypic   Mutations/Phenotypic

    This study contains curated mouse gene mutation data extracted from the Mouse Genome Database (MGD) at The Jackson Laboratory, Bar Harbor, Maine. Additional computational processing and curation of mouse phenotype data was performed to further organize and group data from related phenotypes into uni…

    Source: NextBio Library/Mutation and Phenotypic data

  • p16INK4A transcriptional targets in melanoma

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    Expression profiles of 17 melanoma cell lines were analysed to identify genes differentially expressed between cell lines harbouring wild-type or mutant p16INK4A. Relevant paper: Pavey et al. (2007). Note: all of these cell lines contained wild-type p14ARF, so that the transcriptional effects of p16…

    Authors: Hayward NK, Pavey SJ, Packer LM et al.

    Organization: Queensland Institute of Medical Research…
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Associated Researchers

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Thought leaders and organizations working on research involving TYRP1.

View All Author iconAuthors
  • Bernd Nilius
  • Friedrich Beermann
  • Alan N Houghton
  • X Z Shawn Xu
  • Zhaoyang Feng
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • National Cancer Institute (NCI)
  • National Human Genome Research Institute (NHGRI)
View All Affiliations icon Organizations
  • University of California
  • University of Michigan
  • Memorial Sloan-Kettering Cancer Center
  • National Cancer Institute
  • Hebrew University-Hadassah Medical School

Clinical Trials | 3 trials

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