NextBio

Help

thymidylate synthetase

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq]

View Gene Details



Data Correlations | 1,749 studies

Help for Data Correlations View All
Tissues category icon Normal tissues
Score Help
B lymphoblast 100 100
Femur 90 90
Thymus 81 81
Viscerocranial mucos… 74 74
Cecum 72 72
Fetal organ 72 72
View Top Normal tissues
Compounds category icon Compounds
Score Help
Folinate 100 100
Raltitrexed 100 100
Floxuridine 100 100
Pemetrexed 100 100
Xeloda 100 100
Fluorouracil 99 99
View Top Compounds
Diseases category icon Diseases
Score Help
Adult T-cell leukemi… 100 100
Tuberculosis 99 99
Gram positive septic… 98 98
HIV infection 97 97
Vaccine reaction 97 97
Adrenal carcinoma 94 94
View Top Diseases

Individual Studies

  • Drug target sets for approved compounds

    score: 100100 | Homo sapiens Homo sapiens | Therapeutic   Therapeutic

    The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

    Authors: David S Wishart, Craig Knox, An Chi Guo et al.

    Organization: Department of Computing Science, Univers…

  • Differential susceptibility to Candida albicans in mice

    score: 100100 | Mus musculus Mus musculus | RNA Expression   RNA Expression

    C5-deficiency in the A/J and recombinant congenic strain, BcA17, is linked to a dysregulated inflammatory response to Candida albicans infection and high morbidity compared to C5-sufficient C57Bl/6J (B6) mice. The recombinant congenic BcA70 strain thus provides an ideal model to study the effect of …

    Authors: Mullick A, Leon Z, Min-Oo G et al.

    Organization: McGill University Biochemistry Montreal …
View All Individual Studies

Associated Researchers

Help for Associated Researchers

Thought leaders and organizations working on research involving TYMS.

View All Author iconAuthors
  • Tin Aung
  • Lisandro M Sakata
  • Hon-Tym Wong
  • J J Strain
  • Colin A Boreham
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • National University Hospital, Singapore
  • Vanderbilt-Ingram Cancer Center
  • National Cancer Institute (NCI)
  • National Taiwan University Hospital
View All Affiliations icon Organizations
  • University of Bergen
  • University of Pennsylvania School of Medicine
  • Tan Tock Seng Hospital
  • Johns Hopkins University School of Medicine
  • University of Minnesota

Clinical Trials | 4 trials

Help for Clinical Trials View All

News | 2 stories

Help for News View All

Community

Help for Community
View All NextBio Users | 2 people
NextBio Groups

  • No NextBio groups were found for “TYMS”.
    Be the first to start a group and share your interests with others within the NextBio community.

© 2010 NextBio