TSC2 - NextBio

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Search Term: TSC2 (gene)

Overview

tuberous sclerosis 2

Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]

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Data Correlations | 923 studies

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Normal tissues

Score

Pituitary gland

100

Thyroid gland

Caudate nucleus

Uterus

Preoptic area

Ganglion of cranial …

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Compounds

Score

Bucladesine Sodium

100

Parbendazole

Octyl Phenol

C14209

Fusarinic Acid

Resveratrol

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Diseases

Score

Tuberous sclerosis

100

Pulmonary lymphangio…

100

Hamartoma

Renal cell carcinoma

Escherichia coli inf…

Sendai virus infecti…

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Individual Studies
Mouse Phenotypes - Neurocutaneous syndrome score: 100 \| Mus musculus \| Mutations/Phenotypic This study contains curated mouse gene mutation data extracted from the Mouse Genome Database (MGD) at The Jackson Laboratory, Bar Harbor, Maine. Additional computational processing and curation of mouse phenotype data was performed to further organize and group data from related phenotypes into uni… Source: NextBio Library/Mutation and Phenotypic data	Cancer census - gene mutations in cancer and other diseases score: 100 \| Homo sapiens \| Mutations/Phenotypic The Cancer Gene Census is an ongoing effort to catalogue those genes for which mutations have been causally implicated in cancer. The original census and analysis was published in Nature Reviews Cancer Authors: P Andrew Futreal, Lachlan Coin, Mhairi Marshall et al. Organization: Cancer Genome Project, Human Genome Anal…

Individual Studies

Mouse Phenotypes - Neurocutaneous syndrome

score: 100 | Mus musculus | Mutations/Phenotypic

This study contains curated mouse gene mutation data extracted from the Mouse Genome Database (MGD) at The Jackson Laboratory, Bar Harbor, Maine. Additional computational processing and curation of mouse phenotype data was performed to further organize and group data from related phenotypes into uni…

Source: NextBio Library/Mutation and Phenotypic data

Cancer census - gene mutations in cancer and other diseases

score: 100 | Homo sapiens | Mutations/Phenotypic

The Cancer Gene Census is an ongoing effort to catalogue those genes for which mutations have been causally implicated in cancer. The original census and analysis was published in Nature Reviews Cancer

Authors: P Andrew Futreal, Lachlan Coin, Mhairi Marshall et al.

Organization: Cancer Genome Project, Human Genome Anal…