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tripartite motif-containing 63

This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is localized to the Z-line and M-line lattices of myofibrils, where titin's N-terminal and C-terminal regions respectively bind to the sarcomere. In vitro binding studies have shown that this protein also binds directly to titin near the region of titin containing kinase activity. Another member of this protein family binds to microtubules. Since these family members can form heterodimers, this suggests that these proteins may serve as a link between titin kinase and microtubule-dependent signal pathways in muscle. [provided by RefSe...

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Data Correlations | 417 studies

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Tissues category icon Normal tissues
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Quadriceps femoris 100 100
Superior surface of … 91 91
Superior vena cava 86 86
Viscerocranial mucos… 85 85
Tongue 84 84
Subdivision of nucle… 84 84
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Compounds category icon Compounds
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Sodium Pyruvate 100 100
Chromium(3 ) 3-pyrid… 86 86
Ng-nitroarginine Met… 71 71
Proteoglycan 67 67
Methylprednisolone 59 59
Cyclodextrin-benzald… 55 55
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Diseases category icon Diseases
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Alveolar soft part s… 100 100
Metastasis from mali… 85 85
Fracture of femur 83 83
Myasthenia gravis 75 75
Melanoma 74 74
Malnutrition 68 68
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Individual Studies

  • Muscle Atlas Hs: Relative gene expression

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    There is a consistent variation in the response of different skeletal muscle groups to mutations in genes known to cause muscular dystrophy, yet these muscles appear histologically similar. To better understand these phenotypic differences, we analyzed gene expression patterns in control muscle spec…

    Authors: Kang PB, Kho AT, Sanoudou D et al.

    Organization: Children's Hospital Boston 300 Longwood …

  • Gene Expression Profiling of Alveolar Soft-Part Sarcoma (ASPS)

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    For seven patients with confirmed primary or metastatic ASPS, RNA samples were isolated immediately following surgery, reverse transcribed to cDNA and each sample hybridized to duplicate high-density human U133 plus 2.0 microarrays. Array data was then analyzed relative to arrays hybridized to unive…

    Authors: Stockwin H Luke, Vistica T David, Kenney Susan et al.

    Organization: NCI Frederick DTP Ft. Detrick Frederick …
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Associated Researchers

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Thought leaders and organizations working on research involving TRIM63.

View All Author iconAuthors
  • Siegfried Labeit
  • Christian C Witt
  • David J Glass
  • Richard H Buckingham
  • Liliana Mora
View All Affiliations icon Organizations
  • University of North Carolina
  • Uppsala University
  • University of California
  • University of Tokyo
  • Katholieke Universiteit Leuven

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