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TNF receptor-associated factor 4
This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-len...
Normal tissues
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|
||
|---|---|---|---|
| Caudate nucleus |
100
|
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| Bronchus |
99
|
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| Salivary gland |
98
|
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| Uterus |
95
|
||
| Superior surface of … |
93
|
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| Adrenal gland |
93
|
Compounds
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|
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|---|---|---|---|
| Tolbutamide |
100
|
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| Phenelzine |
86
|
||
| 2,4-dinitrophenylhyd… |
84
|
||
| Harpagoside |
81
|
||
| Glycocholate |
76
|
||
| Budesonide |
76
|
 Individual Studies |
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Homo sapiens
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RNA Expression
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TRAF4 overexpression is a common characteristic of human carcinomas.
Authors: S Camilleri-Broët, I Cremer, B Marmey, E Comperat, F Viguié, J Audouin, M-C Rio, W-H Fridman, C Sautès-Fridman, C H Régnier
Oncogene 2007 Jan 4 -
TRAF4 is potently induced by TAp63 isoforms and localised according to differentiation in SCCHN.
Authors: Xiaolian Gu, Philip J Coates, Stephanie F MacCallum, Linda Boldrup, Björn Sjöström, Karin Nylander
Cancer biology & therapy 2007 Dec
Thought leaders and organizations working on research involving TRAF4.
- Erdyni N Tsitsikov
- Valérie Kedinger
- Elaine F Remmers
- Ann B Begovich
- Michiko K Oyoshi
- Université Pierre et Marie Curie
- University of Texas M. D. Anderson Cancer Center
- Children's Hospital
- Umeå University
- King's College London
