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TNF receptor-associated factor 1

The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found t...

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Data Correlations | 1,055 studies

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Tissues category icon Normal tissues
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Mesenteric lymph nod… 100 100
Salivary gland 79 79
Thyroid gland 77 77
Caudate nucleus 77 77
Adrenal gland 76 76
B lymphoblast 76 76
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Compounds category icon Compounds
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Acetylcysteine 100 100
Aids070130 80 80
Nsc635257 70 70
Mesatp Cpd 69 69
Paeonol 66 66
Aicar 66 66
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Diseases category icon Diseases
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Mycosis fungoides 100 100
Tuberculosis 93 93
Scarlet fever 91 91
Measles 87 87
Helicobacter pylori … 86 86
Zoonotic bacterial d… 84 84
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Individual Studies

  • Polarized T84 cells response to H. pylori infection

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    we characterized the interaction between H. pylori and human T84 epithelial cell polarized monolayers.

    Authors: Merrell S Douglas

    Organization: Stanford Microarray Database (SMD) Stanf…

  • B Cell Response to Short-Term Stimulation with 33 Single Ligands

    score: 100100 | Mus musculus Mus musculus | RNA Expression   RNA Expression

    Major Patterns of B Cell Gene Expression Changes in Response to Short-Term Stimulation with 33 Single Ligands

    Authors: Hart Rebecca, Chang Mi Sook, Kim Jong-Woo et al.

    Organization: California Institute of Technology Biolo…
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Associated Researchers

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Thought leaders and organizations working on research involving TRAF1.

View All Author iconAuthors
  • Bharat B Aggarwal
  • Erdyni N Tsitsikov
  • Ann B Begovich
  • Annette T Lee
  • Kwang Seok Ahn
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Washington University School of Medicine
View All Affiliations icon Organizations
  • University of Texas M D Anderson Cancer Center
  • Children's Hospital
  • University of Toledo Health Science Campus
  • Feinstein Institute for Medical Research
  • Leiden University Medical Centre

Clinical Trials | 1 trial

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Community

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