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tropomyosin 1 (alpha)

This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contra...

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Data Correlations | 2,167 studies

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Tissues category icon Normal tissues
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Great saphenous vein 100 100
Myometrium 94 94
Vagina 93 93
Cecum 90 90
Cardiac atrium 89 89
Small intestine 87 87
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Compounds category icon Compounds
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Aristolochic Acid 100 100
Tribenoside 82 82
Hycanthone 82 82
Sapphyrin 81 81
Nitrosomethylurethan… 81 81
Tipifarnib 79 79
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Diseases category icon Diseases
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Cardiomyopathy 100 100
Knee osteoarthritis 100 100
Colitis 89 89
Chronic fatigue synd… 87 87
Peripheral T-cell ly… 80 80
Bipolar disorder 78 78
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Individual Studies

  • Genomic profile of dextran sulphate sodium-induced colitis model in rats

    score: 100100 | Rattus norvegicus Rattus norvegicus | RNA Expression   RNA Expression

    Dextran sulphate sodium (DSS) induced colitis in rats is one of the most widely used models of inflammatory bowel disease. Animal models can provide new insights into the pathogenesis of intestinal inflammation.

    Authors: Montero Trinidad, Suárez Antonio, Llor Xavier et al.

    Organization: University of Granada Biochemistry and M…
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Associated Researchers

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Thought leaders and organizations working on research involving TPM1.

View All Author iconAuthors
  • William Lehman
  • Peter W Gunning
  • Shantaram Bharadwaj
  • R John Solaro
  • Roger Craig
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • National Heart, Lung, and Blood Institute (NHLBI)
  • Children's Hospital Boston
View All Affiliations icon Organizations
  • Children's Hospital at Westmead
  • Boston University School of Medicine
  • Children's Medical Research Institute
  • University of Cincinnati Medical Center
  • Le Centre de recherche en cancérologie de l'Université Laval

Clinical Trials | 2 trials

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Community

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