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tumor necrosis factor (ligand) superfamily, member 4

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF4/OX4. It is found to be involved in T cell antigen-presenting cell (APC) interactions. In surface Ig- and CD40-stimulated B cells, this cytokine along with CD70 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells. [provided by RefSeq]

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Data Correlations | 742 studies

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Tissues category icon Normal tissues
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Adrenal gland 100 100
Uterus 99 99
Set of pancreatic is… 99 99
Subthalamic nucleus 97 97
Globus pallidus 97 97
Thyroid gland 97 97
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Compounds category icon Compounds
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Noc 18 100 100
Escherichia Coli 95 95
Gamma Rays 94 94
Hydrogen Peroxide 92 92
Althiazide 90 90
Nsc720094 90 90
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Diseases category icon Diseases
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Insulin dependent di… 100 100
Cardiomyopathy 99 99
Exacerbation of asth… 99 99
Blunt injury 93 93
Pre B-cell acute lym… 89 89
Common acute lymphob… 89 89
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Individual Studies

  • Activated peripheral blood T cell response to oxidative stress

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    T cells isolated from peripheral blood were cultured with CD3, CD28, and IL-2 to induce T-cell activaiton. Samples were splited into two parts before the cutlure started, one treated with 25 uM H2O2 for 10 minutes, the other intact.

    Authors: Wang Min, Papoutsakis T Eleftherios

    Organization: Northwestern University Chemical and Bio…
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Associated Researchers

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Thought leaders and organizations working on research involving TNFSF4.

View All Author iconAuthors
  • Hideo Yagita
  • Elizabeth L McMonagle
  • Ann B Hill
  • Toshiyuki Hori
  • Ren-gao Ye
View All Affiliations icon Organizations
  • Kyoto University
  • University of Glasgow
  • Sun Yat-sen University
  • Oregon Health and Science University
  • Juntendo University School of Medicine

Community

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