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tumor necrosis factor receptor superfamily, member 9
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. [provided by RefSeq]
Normal tissues
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|---|---|---|---|
| Peripheral blood mon… |
100
|
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| T lymphocyte |
90
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| Superior surface of … |
88
|
||
| Trigeminal ganglion |
87
|
||
| Globus pallidus |
85
|
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| Bronchus |
85
|
Compounds
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|
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|---|---|---|---|
| Noc 18 |
100
|
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| Thymoglobulin |
98
|
||
| Lac B |
97
|
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| Crystalbumins |
95
|
||
| Paeonol |
93
|
||
| Baker's Yeast (sacch… |
92
|
 Individual Studies |
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|---|---|
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Mus musculus
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RNA Expression
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Identification of regulatory functions for 4-1BB and 4-1BBL in myelopoiesis and the development of dendritic cells.
Authors: Seung-Woo Lee, Yunji Park, Takanori So, Byoung S Kwon, Hilde Cheroutre, Robert S Mittler, Michael Croft
Nature immunology 2008 Aug -
CD137 (4-1BB) deficiency reduces atherosclerosis in hyperlipidemic mice.
Authors: Hyung Jun Jeon, Jae-Hoon Choi, In-Hyuk Jung, Jong-Gil Park, Mi-Ran Lee, Mi-Ni Lee, Bora Kim, Ji-Young Yoo, Se-Jin Jeong, Dae-Yong Kim,…
Circulation 2010 Mar 9
Thought leaders and organizations working on research involving TNFRSF9.
- Bristol-Myers Squibb
- Fred Hutchinson Cancer Research Center
- University of Pennsylvania
- National Institute of Allergy and Infectious Diseases (NIAID)
- Mayo Clinic
- University of Ulsan
- La Jolla Institute for Allergy and Immunology
- University of Toronto
- Indiana University School of Medicine
- Ewha Womans University
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Adoptive Cellular Immunotherapy With Gene-Modified T Cells in Treating Patients With Relapsed or Refractory Mantle Cell Lymphoma or Indolent B-Cell Non-Hodgkin Lymphoma
conditions: Lymphoma
interventions: aldesleukin ; therapeutic autologous lymphocytes ; fludarabine phosphate ; gene rearrangement analysis ; polymerase chain reaction ; western blotting ; biopsy
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Study of Neoadjuvant Ipilimumab in Patients With Urothelial Carcinoma Undergoing Surgical Resection
conditions: Urothelial Carcinoma
interventions: Ipilimumab
Community
Xavier Frigola
Research Techologist I
MayoClinic
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