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tumor necrosis factor receptor superfamily, member 10b

The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq]

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Data Correlations | 1,199 studies

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Tissues category icon Normal tissues
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Adrenal gland 100 100
Caudate nucleus 96 96
Bronchus 95 95
Pericardium 93 93
Adrenal cortex 92 92
Fetus 90 90
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Compounds category icon Compounds
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Levobunolol 100 100
Denatonium Benzoate 95 95
Black Cohosh Extract 82 82
Cefaclor 80 80
Phensuximide 80 80
Gamma Rays 80 80
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Diseases category icon Diseases
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Squamous cell carcin… 100 100
Polycystic ovary syn… 100 100
Urinary tract infect… 96 96
Renal failure 96 96
Hodgkin disease, nod… 95 95
Drug toxicity 94 94
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Individual Studies

  • OMIM - Malignant neoplasms

    score: 100100 | Homo sapiens Homo sapiens | Mutations/Phenotypic   Mutations/Phenotypic

    This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories.

    Source: NextBio Library/Mutation and Phenotypic data

  • Broad Connectivity Map (CMAP 2.0) compound database

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    A reference collection of genome-wide transcriptional expression data from cultured human cells treated with bioactive small molecules that enable the discovery of functional connections between drugs, genes and diseases through the transitory feature of common gene-expression changes.

    Authors: Lamb J

    Organization: Broad Institute Seven Cambridge Center C…
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Associated Researchers

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Thought leaders and organizations working on research involving TNFRSF10B.

View All Author iconAuthors
  • Taeg Kyu Kwon
  • Kyeong Sook Choi
  • Ping Yue
  • Fadlo R Khuri
  • Eun Hee Kim
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Mayo Clinic
  • Amgen
  • Memgen, LLC
  • M.D. Anderson Cancer Center
  • Genentech
View All Affiliations icon Organizations
  • Emory University School of Medicine
  • Ajou University School of Medicine
  • Georgetown University Medical Center
  • Genentech Inc
  • Center for Hematology and Oncology Molecular Therapeutics

Clinical Trials | 9 trials

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Community

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