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toll-like receptor 5

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene product is expressed in myelomonocytic cells, and recognizes bacterial flagellin, a principal component of bacterial flagella and a vi...

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Data Correlations | 747 studies

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Tissues category icon Normal tissues
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Vagina 100 100
Epidermis 97 97
Superior surface of … 93 93
Substantia nigra 89 89
Medulla of kidney 89 89
Salivary gland 88 88
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Compounds category icon Compounds
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SID 7978801 100 100
Fluorouracil 82 82
Imipenem 81 81
Endotoxin 78 78
Sevoflurane 76 76
Allantoin 74 74
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Diseases category icon Diseases
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Legionnaires disease 100 100
Systemic lupus eryth… 99 99
Gp A streptococcal s… 72 72
Septic shock 59 59
Septicemia due to St… 59 59
Exacerbation of asth… 52 52
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Individual Studies

  • OMIM - Lung diseases

    score: 100100 | Homo sapiens Homo sapiens | Mutations/Phenotypic   Mutations/Phenotypic

    This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories.

    Source: NextBio Library/Mutation and Phenotypic data
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Associated Researchers

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Thought leaders and organizations working on research involving TLR5.

View All Author iconAuthors
  • Shizuo Akira
  • Satoshi Uematsu
  • Andrew T Gewirtz
  • Jean-Claude Sirard
  • Masayuki Miyasaka
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • University of Thessaly
  • VaxInnate Corporation
  • Medical College of Wisconsin
View All Affiliations icon Organizations
  • Osaka University
  • Emory University
  • Institute for Systems Biology
  • Emory University School of Medicine
  • Utrecht University

Community

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