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toll-like receptor 2

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimul...

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Data Correlations | 1,091 studies

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Tissues category icon Normal tissues
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Segment of large int… 100 100
Femur 99 99
Peripheral blood mon… 98 98
Monocyte 97 97
Ganglion of cranial … 95 95
Synovial membrane 94 94
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Compounds category icon Compounds
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Haemophilus Influenz… 100 100
Concanavaline A 98 98
Aids070130 73 73
Mesatp Cpd 71 71
Manlam 69 69
9-fluoroprednisolone 69 69
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Diseases category icon Diseases
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Leprosy 100 100
Colorectal Cancer 99 99
Anthrax 99 99
Liver disorder due t… 94 94
Hemorrhage 84 84
Helicobacter-associa… 81 81
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Individual Studies

  • OMIM - Mycobacteriosis

    score: 100100 | Homo sapiens Homo sapiens | Mutations/Phenotypic   Mutations/Phenotypic

    This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories.

    Source: NextBio Library/Mutation and Phenotypic data

  • Gene expression in respiratory epithelial cells treated to induce stimulated innate resistance

    score: 100100 | Mus musculus Mus musculus | RNA Expression   RNA Expression

    Pneumonia is a serious problem worldwide. To determine the breadth of protection conferred by stimulation of lung mucosal innate immunity, and to identify cells and signaling pathways activated by this treatment, mice were treated with an aerosolized bacterial lysate, then challenged with lethal dos…

    Organization: University of Texas-M.D. Anderson Cancer…
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Associated Researchers

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Thought leaders and organizations working on research involving TLR2.

View All Author iconAuthors
  • Shizuo Akira
  • Atsushi Kitani
  • Tomohiro Watanabe
  • Warren Strober
  • Sang-Gi Paik
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Johann Wolfgang Goethe University Hospitals
  • University of Thessaly
  • Chang Gung Memorial Hospital
  • Medical College of Wisconsin
  • Medical Universtity of Lodz
View All Affiliations icon Organizations
  • University of California
  • National Institute of Allergy and Infectious Diseases
  • University of Glasgow
  • Osaka University
  • University of Oxford

Clinical Trials | 9 trials

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Community

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