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TEK tyrosine kinase, endothelial
The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase. [provided by RefSeq]
Normal tissues
|
|
||
|---|---|---|---|
| Adrenal gland |
100
|
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| Thyroid gland |
91
|
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| Adrenal cortex |
89
|
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| Medulla of kidney |
89
|
||
| Penis |
87
|
||
| Synovial membrane |
87
|
Compounds
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|
||
|---|---|---|---|
| Todralazine |
100
|
||
| Graveoline |
93
|
||
| Articaine |
85
|
||
| Nsc285166 |
78
|
||
| Tomatidenol |
74
|
||
| Etofenamate |
72
|
 Individual Studies |
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|---|---|
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Homo sapiens
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Mutations/Phenotypic
Mus musculus
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Somatic mutations in angiopoietin receptor gene TEK cause solitary and multiple sporadic venous malformations.
Authors: Nisha Limaye, Vinciane Wouters, Melanie Uebelhoer, Marjut Tuominen, Riikka Wirkkala, John B Mulliken, Lauri Eklund, Laurence M Boon, Miikka Vikkula
Nature genetics 2009 Jan -
Runx1 function in hematopoiesis is required in cells that express Tek.
Authors: Zhe Li, Michael J Chen, Terryl Stacy, Nancy A Speck
Blood 2006 Jan 1
Thought leaders and organizations working on research involving TEK.
- Montefiore Medical Center
- Yale University
- University of Mersin School of Medicine
- Sunnybrook and Women's College Research Institute
- Yale University School of Medicine
- Centre Hospitalier et Universitaire Nord
- Université Catholique de Louvain
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Randomized, Controlled, Double Blind Trial of Eszopiclone for Insomnia Associated With Schizophrenia
conditions: Insomnia ; Schizophrenia ; Schizoaffective Disorder ; Sleep Disorders
interventions: Eszopiclone ; Placebo
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Pilot Trial of Naltrexone for Obesity in Women With Schizophrenia
conditions: Obesity ; Schizophrenia ; Schizoaffective Disorder
interventions: Naltrexone 25mg ; Placebo
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Smart-Tek Implements Healthcare Initiative
PR Newswire. - January 21, 2010 -
Smart-Tek Automated Services rolls out its healthcare initiative for 2010
News-Medical. - January 22, 2010
