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transcobalamin II; macrocytic anemia

This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This plasma protein binds cobalamin and mediates the transport of cobalamin into cells. This protein and other mammalian cobalamin-binding proteins, such as transcobalamin I and gastric intrisic factor, may have evolved by duplication of a common ancestral gene. [provided by RefSeq]

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Data Correlations | 1,365 studies

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Tissues category icon Normal tissues
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Vomeronasal organ 100 100
Colon 98 98
Femur 95 95
Cecum 90 90
Spinal cord 87 87
Caudate nucleus 87 87
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Compounds category icon Compounds
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Cyanokit 100 100
Cyanocobalamin 99 99
Alpha-melanotropin 66 66
Triatomic Oxygen 65 65
Fhpi 62 62
Oxirane 56 56
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Diseases category icon Diseases
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Transcobalamin II de… 100 100
Exacerbation of asth… 53 53
Vaccine reaction 45 45
Influenza 45 45
Hypertensive disease 44 44
Hypoxia 42 42
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Individual Studies

  • OMIM - Congenital disorder

    score: 100100 | Homo sapiens Homo sapiens | Mutations/Phenotypic   Mutations/Phenotypic

    This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories.

    Source: NextBio Library/Mutation and Phenotypic data

  • Drug target sets for approved compounds

    score: 100100 | Homo sapiens Homo sapiens | Therapeutic   Therapeutic

    The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

    Authors: David S Wishart, Craig Knox, An Chi Guo et al.

    Organization: Department of Computing Science, Univers…
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Associated Researchers

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Thought leaders and organizations working on research involving TCN2.

View All Author iconAuthors
  • Serban Costa
  • Jacobus Pfisterer
  • Andreas du Bois
  • Gere Sunder-Plassmann
  • Hans-Joachim Lück
View All Affiliations icon Organizations
  • University of Bergen
  • University of California
  • Medical University of Vienna
  • University Henry Poincaré of Nancy
  • Brigham and Women's Hospital

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