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transcription factor 4

This gene encodes transcription factor 4, a basic helix-turn-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is expressed predominantly in pre-B-cells, although it is found in other tissues as well. Defects in this gene are a cause of Pitt-Hopkins syndrome. Multiple alternatively spliced transcript variants that encode different proteins have been described. [provided by RefSeq]

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Data Correlations | 2,181 studies

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Tissues category icon Normal tissues
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Synovial membrane 100 100
Myometrium 97 97
Small intestine 95 95
Subdivision of nucle… 93 93
Lateral nuclear grou… 92 92
Fetal organ 89 89
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Compounds category icon Compounds
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Sparteine 100 100
Aethophyllinum 91 91
Piperine 87 87
CID 5140203 85 85
Tomatidenol 82 82
Spectinomycin 81 81
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Diseases category icon Diseases
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Diabetes mellitus 100 100
B-cell chronic lymph… 100 100
Radiation injury 97 97
Aggressive fibromato… 94 94
Acute leukemia 93 93
Clear cell carcinoma… 92 92
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Individual Studies

  • HeLa cells with RNAi targetting A1 hnRNP, FUS, H hnRNP and p68-DDX5

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    Four different RNA interference targets were compared in HeLa cells: A1 hnRNP (HNRNPA1, Heterogeneous nuclear ribonucleoprotein A1); FUS (fusion gene, involved in t(12;16) in malignant liposarcoma); H hnRNP (HNRNPH1); and p68 helicase (DDX5, DEAD (Asp-Glu-Ala-Asp) box polypeptide 5).

    Authors: Camats M, Guil S, Kokolo M et al.

    Organization: CRG Passeig Maritim 37-49 Barcelona 0800…

  • Forebrain Neurons Atlas_Mm: Relative gene expression

    score: 100100 | Mus musculus Mus musculus | RNA Expression   RNA Expression

    The mammalian forebrain is a tissue of stunning complexity comprised of numerous regions each containing many distinct cell types that differ in their intrinsic and synaptic physiology, morphology and connectivity. These differences are likely conferred by differential gene expression, but the exten…

    Authors: Sugino K, Hempel CM, Nelson SB

    Organization: Brandeis University Biology Nelson 415 S…
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Associated Researchers

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Thought leaders and organizations working on research involving TCF4.

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  • Unnur Thorsteinsdottir
  • Hans Clevers
  • Mark I McCarthy
  • Augustine Kong
  • Karen L Mohlke
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  • National Institute for Health and Welfare, Finland
View All Affiliations icon Organizations
  • Hubrecht Institute
  • National Cancer Center Research Institute
  • University of Michigan
  • Rockefeller University
  • CR UK London Research Institute

Clinical Trials | 1 trial

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Community

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