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TANK-binding kinase 1

The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. For example, the protein can form a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK. [provided by RefSeq]

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Data Correlations | 1,292 studies

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Tissues category icon Normal tissues
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Mesenteric lymph nod… 100 100
Femur 89 89
Cecum 85 85
Trigeminal ganglion 84 84
Deltoid 83 83
Vagina 82 82
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Compounds category icon Compounds
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Cytisine 100 100
Echinomycin 98 98
Oxayohimban-16-carbo… 92 92
Isochlorogenic Acid 90 90
Piracetam 90 90
Adenosine Triphospha… 89 89
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Diseases category icon Diseases
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Infection by Nippost… 100 100
Chronic stress disor… 95 95
Multiple benign mela… 87 87
Acute lymphoid leuke… 78 78
Crush injury, multip… 77 77
Postpartum cardiomyo… 75 75
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Individual Studies

  • Hypoxic changes in gene expression: effect of vhl and p53 genotype

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    Microarrray experiments were performed in order to identify genes whose expression is altered under hypoxic conditions and to determine whether these changes are dependant on the p53 and HIF tanscription factors.

    Authors: Papandreou Ioanna, Cairns A Rob, Fontana Lucrezia et al.

    Organization: Stanford University Radiation Oncology R…
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Associated Researchers

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Thought leaders and organizations working on research involving TBK1.

View All Author iconAuthors
  • Shizuo Akira
  • Taro Kawai
  • John Hiscott
  • Ken J Ishii
  • Fumihiko Takeshita
View All Affiliations icon Organizations
  • University of California
  • McGill University
  • University of Massachusetts Medical School
  • Japan Science and Technology Agency
  • Second Military Medical University

Community

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