The process whereby a relatively unspecialized hemopoietic stem cell acquires the specialized features of a T cell.

Data Correlations | 2,130 studies

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Normal tissues	Score
Mesenteric lymph nod…	100
Caudate nucleus	67
Adrenal gland	65
Cecum	65
Bronchus	64
Zygote	61

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Compounds	Score
Interferon Gamma	100
Aids070130	100
Staphylococcal Enter…	97
Dinitrofluorobenzene	96
Infliximab	95
Gamma Rays	94

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Diseases	Score
Neoplasm of thymus	100
Grade I acute reject…	96
Tympanic membrane pe…	93
Smallpox	91
Bordetella	88
Complication of tran…	86

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Individual Studies
Gene expression profiling of experimental asthma induced by OVA challenge score: 100 | Mus musculus |   RNA Expression Three groups of mice (6 mice/group) were sensitized and challenged with allergen (OVA), one group (control group) was sensitized and challenged with placebo (PBS) and served as a control. Source: NextBio Library/Immune response and infection	Effects of microRNA-155 and EBV-infection score: 91 | Homo sapiens |   RNA Expression The EBV positive Burkitt's lymphoma cell line, Akata was infected with a control or a microRNA-155 expressing retrovirus, or EBV positive and EBV negative Burkitt's lymphoma cells were compared. Organization: Tulane Health Sciences Center Pathology …

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Literature | 151,286 results

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• Foxp3+ regulatory T cells: differentiation, specification, subphenotypes.

  Authors: Markus Feuerer, Jonathan A Hill, Diane Mathis, Christophe Benoist

  Nature immunology 2009 Jul

• TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation.

  Authors: Yong-Jun Liu, Vasilli Soumelis, Norihiko Watanabe, Tomoki Ito, Yui-Hsi Wang, Rene de Waal Malefyt, Miyuki Omori, Baohua Zhou, Steven F Ziegler

  Annual review of immunology 2007

Associated Researchers

Thought leaders and organizations working on research involving T cell differentiation.

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• Susan M Kaech
• Richard A Flavell
• Estelle Bettelli
• Mohamed Oukka
• Rene de Waal Malefyt

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• National Institute of Allergy and Infectious Diseases (NIAID)
• National Cancer Institute (NCI)
• Radboud University
• Mackay Memorial Hospital
• European Organization for Research and Treatment of Cancer

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• Yale University School of Medicine
• National Cancer Institute
• Emory University School of Medicine
• Harvard Medical School
• Ghent University Hospital

Clinical Trials | 74 trials

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• Characterization of Interferon Beta -1b-Induced Tolerizing Effect in Dendritic Cells

  conditions: Multiple Sclerosis

  interventions: INFNb-1b

   

• Toll-like Receptor (TLR) Ligand Matured Dendritic Cell Vaccination in Melanoma Patients

  conditions: Melanoma

  interventions: autologous dendritic cell vaccination

   

News | 9 stories

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• Dynamic changes in the human methylome during differentiation [LETTERS]

  Genome Research. - March 02, 2010

• [METHODS] Distinct DNA methylation patterns characterize differentiated human embryonic stem cells and developing human fetal liver

  Genome Research. - May 31, 2009

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  University of Chicago

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