sterol O-acyltransferase 1

Acyl-coenzyme A:cholesterol acyltransferase (ACACT; EC 2.3.1.26) is an intracellular protein located in the endoplasmic reticulum that forms cholesterol esters from cholesterol. Accumulation of cholesterol esters as cytoplasmic lipid droplets within macrophages and smooth muscle cells is a characteristic feature of the early stages of atherosclerotic plaques (Cadigan et al., 1988 [PubMed 3335499]).[supplied by OMIM]

Data Correlations | 1,862 studies

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Normal tissues	Score
Adrenal cortex	100
Epidermis	99
Fat body	97
Vomeronasal organ	93
Blastocyst	87
Mesenteric lymph nod…	87

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Compounds	Score
Hesperetin	100
Fenbufen	78
Pralidoxime Chloride	77
Cerivastatin	71
Rotenone	67
Crystal Violet	66

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Diseases	Score
Neoplasm of vulva	100
Cholangiocarcinoma o…	93
Hypoxic-ischemic bra…	89
Spinal cord injuries	88
Effects of exposure …	87
Hodgkin disease, nod…	84

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Individual Studies

Drug target sets for approved compounds score: 100 | Homo sapiens |   Therapeutic The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information. Authors: David S Wishart, Craig Knox, An Chi Guo et al. Organization: Department of Computing Science, Univers…

Exercise and cerivastatin treated rat skeletal muscles score: 100 | Rattus norvegicus |   RNA Expression Adverse effects of statins include skeletal muscle toxicity; Type II glycolytic fibers are more senstive to statin damage; exercise exacerbates statin muscle degeneration. We used a well-characterized rat model of statin-induced muscle degeneration, at which 1.0 mg/kg/day (high dose) cerivastatin pr… Authors: Seachrist JL, Jiang P, Leininger MT et al. Organization: Pfizer Inc Safety Sciences 2800 Plymouth…

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Literature | 221,340 results

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• Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development.

  Authors: Stephen Malin, Shane McManus, César Cobaleda, Maria Novatchkova, Alessio Delogu, Philippe Bouillet, Andreas Strasser, Meinrad Busslinger

  Nature immunology 2010 Feb

• Engineering signal transduction pathways.

  Authors: Christina Kiel, Eva Yus, Luis Serrano

  Cell 2010 Jan 8

Associated Researchers

Thought leaders and organizations working on research involving STAT.

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• Lothar Hennighausen
• Martin P Zeidler
• Willis X Li
• Weiping Chen
• Song Shi

View All Clinical Trials Sponsors

• H. Lee Moffitt Cancer Center and Research Institute
• Department of Veterans Affairs
• University of Pittsburgh
• Far Eastern Memorial Hospital
• University of Nebraska

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• University of Rochester Medical Center
• National Institute of Diabetes and Digestive and Kidney Diseases
• University of Dundee
• Howard Hughes Medical Institute
• University of Amsterdam

Clinical Trials | 74 trials

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• Supported Treadmill Ambulation Training (STAT) for Patients Diagnosed With Amyotrophic Lateral Aclerosis

  conditions: Amyotrophic Lateral Sclerosis ; Motor Neuron Disease ; Lou Gehrig's Disease

  interventions: Treadmill Exercise

   

• STAT3 DECOY in Head and Neck Cancer

  conditions: Head and Neck Cancer

  interventions: STAT 3 DECOY

   

News | 180 stories

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• Caution: Stats May Be Slippery

  BusinessWeek. - March 11, 2010

• Stat defence

  BBC. - January 11, 2010

Community

View All NextBio Users | 9 people

• Shinsheng  Yuan

• Chiahsin  Liu

View All NextBio Groups | 1 group

• Breast Cancer Integrated Knowledge Group

  26 members

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