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steroidogenic acute regulatory protein

The protein encoded by this gene plays a key role in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnenolone. This protein permits the cleavage of cholesterol into pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane. Mutations in this gene are a cause of congenital lipoid adrenal hyperplasia (CLAH), also called lipoid CAH. A pseudogene of this gene is located on chromosome 13. [provided by RefSeq]

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Data Correlations | 949 studies

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Tissues category icon Normal tissues
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Adrenal cortex 100 100
Adrenal gland 86 86
Interstitial cell of… 62 62
Lymph node 62 62
Epidermis 56 56
Vestibular nuclear c… 56 56
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Compounds category icon Compounds
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Antide 100 100
Pregnant Mare Serum … 99 99
Luteinizing Hormone 98 98
Trilostane 98 98
Follicle Stimulating… 95 95
Hydroxychlor 91 91
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Diseases category icon Diseases
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Cholesterol monooxyg… 100 100
Abdominothoracic neu… 88 88
Adrenal neuroblastom… 88 88
Serous cystadenoma o… 70 70
Ovary Cancer 62 62
Endometrioma 54 54
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Individual Studies

  • Mouse Phenotypes - Autosomal recessive hereditary disorder

    score: 100100 | Mus musculus Mus musculus | Mutations/Phenotypic   Mutations/Phenotypic

    This study contains curated mouse gene mutation data extracted from the Mouse Genome Database (MGD) at The Jackson Laboratory, Bar Harbor, Maine. Additional computational processing and curation of mouse phenotype data was performed to further organize and group data from related phenotypes into uni…

    Source: NextBio Library/Mutation and Phenotypic data
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Associated Researchers

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Thought leaders and organizations working on research involving STAR.

View All Author iconAuthors
  • Anna Frebel
  • Robert D Mathieu
  • G Pagliara
  • Barry F Madore
  • Christopher F McKee
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Link America, Inc.
  • Memorial Sloan-Kettering Cancer Center
  • University Hospital Inselspital, Berne
  • University of Maryland
  • National Institute of Allergy and Infectious Diseases (NIAID)
View All Affiliations icon Organizations
  • Harvard-Smithsonian Center for Astrophysics
  • Instituut voor Sterrenkunde
  • Max-Planck-Institut für extraterrestrische Physik
  • Max Planck Institut für Astrophysik
  • University of Manchester

Clinical Trials | 203 trials

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News | 1,229 stories

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Community

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View All NextBio Users | 8 people
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