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SP110 nuclear body protein
The nuclear body is a multiprotein complex that may have a role in the regulation of gene transcription. This gene is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. In addition, it has been suggested that the protein may play a role in ribosome biogenesis and in the induction of myeloid cell differentiation. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. [provided by RefSeq]
Normal tissues
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|
||
|---|---|---|---|
| Mesenteric lymph nod… |
100
|
||
| Zone of stomach |
88
|
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| Femur |
87
|
||
| Hemisphere of cerebe… |
87
|
||
| Vermis of cerebellum |
86
|
||
| Subthalamic nucleus |
86
|
Compounds
|
|
||
|---|---|---|---|
| Iopamidol |
100
|
||
| Kawain |
99
|
||
| Trolox |
84
|
||
| Probucol |
84
|
||
| Niflumic Acid |
84
|
||
| 4-hydroxyantipyrine |
84
|
Diseases
|
|
||
|---|---|---|---|
| Tuberculosis |
100
|
||
| Pulmonary embolism |
100
|
||
| Chagas' disease |
87
|
||
| Dermatomyositis |
79
|
||
| Staphylococcus aureu… |
78
|
||
| Dengue fever |
72
|
 Individual Studies |
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|---|---|
|
|
Rattus norvegicus
|
RNA Expression
Mus musculus
|
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Mutations in the gene encoding the PML nuclear body protein Sp110 are associated with immunodeficiency and hepatic veno-occlusive disease.
Authors: Tony Roscioli, Simon T Cliffe, Donald B Bloch, Christopher G Bell, Glenda Mullan, Peter J Taylor, Maria Sarris, Joanne Wang, Jennifer A Donald, Edwin P Kirk,…
Nature genetics 2006 Jun -
Ipr1 gene mediates innate immunity to tuberculosis.
Authors: Hui Pan, Bo-Shiun Yan, Mauricio Rojas, Yuriy V Shebzukhov, Hongwei Zhou, Lester Kobzik, Darren E Higgins, Mark J Daly, Barry R Bloom, Igor Kramnik
Nature 2005 Apr 7
Thought leaders and organizations working on research involving SP110.
- Fred Hutchinson Cancer Research Center
- University of Florida
- University of New South Wales
- Wayne State University
- Harvard School of Public Health
- Friedrich-Alexander University
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Cyclophosphamide and Busulfan Followed By Donor Stem Cell Transplant in Treating Patients With Myelofibrosis
conditions: Chronic Myeloproliferative Disorders ; Secondary Myelofibrosis
interventions: busulfan ; cyclophosphamide ; methotrexate ; tacrolimus ; pharmacological study ; allogeneic hematopoietic stem cell transplantation ; peripheral blood stem cell transplantation
