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SP110 nuclear body protein

The nuclear body is a multiprotein complex that may have a role in the regulation of gene transcription. This gene is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. In addition, it has been suggested that the protein may play a role in ribosome biogenesis and in the induction of myeloid cell differentiation. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. [provided by RefSeq]

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Data Correlations | 1,563 studies

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Tissues category icon Normal tissues
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Mesenteric lym… 100 100
Zone of stomac… 88 88
Femur 87 87
Hemisphere of … 87 87
Vermis of cere… 86 86
Subthalamic nu… 86 86
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Compounds category icon Compounds
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Iopamidol 100 100
Kawain 100 100
Probucol 85 85
Niflumic Acid 85 85
4-hydroxyantip… 85 85
Trolox 85 85
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Diseases category icon Diseases
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Tuberculosis 100 100
Pulmonary embo… 100 100
Chagas' diseas… 86 86
Dermatomyositi… 78 78
Staphylococcus… 78 78
N1 71 71
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Individual Studies

  • Rat right ventricle from pulmonary embolism model

    score: 100100 | Rattus norvegicus Rattus norvegicus | RNA Expression   RNA Expression

    Time and dose related expression profiles of rat right heart tissue in microsphere bead model for Pulmonary embolism.

    Authors: Sanapareddy N, Watts JA, Gellar MA et al.

    Organization: Carolinas Healthcare system 1542 Garden …

  • Murine BRD-2-mediated lymphomas

    score: 9999 | Mus musculus Mus musculus | RNA Expression   RNA Expression

    The dual bromodomain protein Brd2 is closely related to the basal transcription factor TAFII250, which is essential for cyclin A transactivation and mammalian cell cycle progression. In transgenic mice, constitutive lymphoid expression of Brd2 causes a malignancy most similar to human diffuse large …

    Authors: Lenburg ME, Sinha A, Faller DV et al.

    Organization: Boston University School of Medicine Gen…
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Associated Researchers

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Thought leaders and organizations working on research involving SP110.

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  • Lucia Notterpek
  • William A Dunn
  • Irina Madorsky
  • Jonathan D Verrier
  • Stephanie A Amici
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Fred Hutchinson Cancer Research Center
View All Affiliations icon Organizations
  • University of Florida
  • Harvard School of Public Health
  • University of New South Wales
  • Nara Institute of Science and Technology
  • Baylor College of Medicine

Clinical Trials | 1 trial

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Community

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