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suppressor of cytokine signaling 3
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq]
Normal tissues
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|---|---|---|---|
| Superior vena cava |
100
|
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| Bronchus |
93
|
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| Great saphenous vein |
92
|
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| Uterine tube |
91
|
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| Pericardium |
88
|
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| Nipple |
88
|
Compounds
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|---|---|---|---|
| Lps |
100
|
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| Thos Streptonigrin |
97
|
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| Aids070130 |
97
|
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| Guanylic Acid |
95
|
||
| Inosinic Acid |
92
|
||
| Nickel Sulphate |
90
|
 Individual Studies |
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Mus musculus
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RNA Expression
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SOCS3 deletion promotes optic nerve regeneration in vivo.
Authors: Patrice D Smith, Fang Sun, Kevin Kyungsuk Park, Bin Cai, Chen Wang, Kenichiro Kuwako, Irene Martinez-Carrasco, Lauren Connolly, Zhigang He
Neuron 2009 Dec 10 -
Intracellular protein therapy with SOCS3 inhibits inflammation and apoptosis.
Authors: Daewoong Jo, Danya Liu, Shan Yao, Robert D Collins, Jacek Hawiger
Nature medicine 2005 Aug
Thought leaders and organizations working on research involving SOCS3.
- Mexican National Institute of Public Health
- University of Aarhus
- The University of North Carolina, Chapel Hill
- Kyushu University
- Tokyo University of Science
- Walter and Eliza Hall Institute of Medical Research and the Cooperativ…
- Keio University School of Medicine
- Walter and Eliza Hall Institute of Medical Research
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Characterization of Interferon Beta -1b-Induced Tolerizing Effect in Dendritic Cells
conditions: Multiple Sclerosis
interventions: INFNb-1b
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Growth Hormone Signaling in Vivo in Humans
conditions: Intracellular Signaling Peptides and Proteins
interventions: Saline infusion ; Human Growth Hormone ; Pegvisomant
