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solute carrier family 6 (neurotransmitter transporter, serotonin), member 4

This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depress...

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Data Correlations | 861 studies

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Tissues category icon Normal tissues
Score Help
Vestibular nuclear c… 100 100
Set of raphe nuclei 98 98
Femur 93 93
Set of fingers 89 89
Shell region of nucl… 88 88
Colon 87 87
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Compounds category icon Compounds
Score Help
Paroxetine (tn) 100 100
Fenfluramine 99 99
Sertraline 99 99
Fluvoxamine 98 98
Citalopram 98 98
Sibutramine 98 98
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Diseases category icon Diseases
Score Help
Obsessive compulsive… 100 100
Carcinoma of lung pa… 62 62
Adenocarcinoma of lu… 60 60
Neuroendocrine carci… 55 55
Disorder of ileum 54 54
Interstitial pneumon… 48 48
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Individual Studies

  • Drug target sets for approved compounds

    score: 100100 | Homo sapiens Homo sapiens | Therapeutic   Therapeutic

    The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

    Authors: David S Wishart, Craig Knox, An Chi Guo et al.

    Organization: Department of Computing Science, Univers…

  • OMIM - Anxiety disorder

    score: 100100 | Homo sapiens Homo sapiens | Mutations/Phenotypic   Mutations/Phenotypic

    This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories.

    Source: NextBio Library/Mutation and Phenotypic data
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Associated Researchers

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Thought leaders and organizations working on research involving SLC6A4.

View All Author iconAuthors
  • Michael R Hayden
  • Roshni R Singaraja
  • Blair R Leavitt
  • Rona K Graham
  • Elena Cattaneo
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • National Institute of Mental Health (NIMH)
  • Department of Veterans Affairs
  • National Taiwan University Hospital
  • Ludwig-Maximilians - University of Munich
  • Medical Corps, Israel Defense Force
View All Affiliations icon Organizations
  • University of British Columbia
  • National Institute of Mental Health
  • McMaster University
  • Massachusetts General Hospital
  • University of Adelaide

Clinical Trials | 15 trials

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Community

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