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solute carrier family 26, member 5 (prestin)

This gene is a member of the SLC26A/SulP transporter family. It encodes a protein that is specifically expressed in outer hair cells (OHCs) of the cochlea and is essential in auditory processing. Intracellular anions are thought to act as extrinsic voltage sensors, which bind to this protein and trigger the conformational changes required for rapid length changes in OHCs. Mutations in this gene have been associated with non-syndromic hearing loss. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]

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Data Correlations | 522 studies

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Tissues category icon Normal tissues
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Intestine 100 100
Synovial membrane 92 92
Penis 86 86
Deltoid 83 83
Cardia of stomach 81 81
Stomach 80 80
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Compounds category icon Compounds
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Methylnitronitrosogu… 100 100
Lithium 100 100
Zinc00028150 98 98
Gemfibrozil 94 94
Indomethacin 93 93
Methylglyoxal 91 91
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Diseases category icon Diseases
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Metastasis from mali… 100 100
Anomaly of chromosom… 93 93
Metastasis from mali… 86 86
Erythema nodosum lep… 85 85
Conn syndrome 84 84
Very mild acute reje… 83 83
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Individual Studies

  • Liver Pharmacology and Xenobiotic Response Repertoire

    score: 100100 | Rattus norvegicus Rattus norvegicus | RNA Expression   RNA Expression

    A definition of RNA expression changes that correlate with liver response programs and an understanding of the similarities and differences in responses to different classes of chemicals would aid in new chemical or drug characterization and add to our understanding of liver biology.

    Authors: Natsoulis G, Pearson CI, Gollub J et al.

    Organization: Iconix Biosciences 325 E. Middlefield Rd…
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Associated Researchers

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Thought leaders and organizations working on research involving SLC26A5.

View All Author iconAuthors
  • Joseph Santos-Sacchi
  • Fred A Pereira
  • Phyllis Gardner
  • Iris Schrijver
  • Claudia Braig
View All Affiliations icon Organizations
  • Yale University School of Medicine
  • University College London
  • Baylor College of Medicine
  • University of Tübingen
  • University of Cincinnati

Community

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