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solute carrier family 25 (carnitine/acylcarnitine translocase), member 20

This gene product is one of several closely related mitochondrial-membrane carrier proteins that shuttle substrates between cytosol and the intramitochondrial matrix space. This protein mediates the transport of acylcarnitines into mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway. Mutations in this gene are associated with carnitine-acylcarnitine translocase deficiency, which can cause a variety of pathological conditions such as hypoglycemia, cardiac arrest, hepatomegaly, hepatic dysfunction and muscle weakness, and is usually lethal in new born and infants. [provided by R...

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Data Correlations | 1,525 studies

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Tissues category icon Normal tissues
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Cecum 100 100
Brown adipose tissue 98 98
Epidermis 95 95
Colon 91 91
Vermis of cerebellum 90 90
Adrenal gland 88 88
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Compounds category icon Compounds
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Levocarnitine 100 100
Oxytetracycline 100 100
Gentian Violet 88 88
Isochlorogenic Acid 80 80
Meloxicam 79 79
Pravastatin 75 75
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Diseases category icon Diseases
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Carnitine acylcarnit… 100 100
Dehydration 58 58
Effects of low tempe… 57 57
Starvation 47 47
Anaplastic astrocyto… 41 41
Vaccine reaction 40 40
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Individual Studies

  • OMIM - Congenital disorder

    score: 100100 | Homo sapiens Homo sapiens | Mutations/Phenotypic   Mutations/Phenotypic

    This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories.

    Source: NextBio Library/Mutation and Phenotypic data

  • Broad Connectivity Map (CMAP 2.0) compound database

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    A reference collection of genome-wide transcriptional expression data from cultured human cells treated with bioactive small molecules that enable the discovery of functional connections between drugs, genes and diseases through the transitory feature of common gene-expression changes.

    Authors: Lamb J

    Organization: Broad Institute Seven Cambridge Center C…
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Associated Researchers

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Thought leaders and organizations working on research involving SLC25A20.

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  • Olga Rejtarová
  • Vito Iacobazzi
  • Petr Hejna
  • Barry S C Leadbeater
  • Ferdinando Palmieri
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Intergroupe Francophone de Cancerologie Thoracique
View All Affiliations icon Organizations
  • University of California
  • Charles University Prague
  • University of Birmingham
  • Rice University
  • Osaka University

Clinical Trials | 1 trial

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Community

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