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solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15

This gene is a member of the mitochondrial carrier family. The encoded protein transports ornithine across the inner mitochondrial membrane from the cytosol to the mitochondrial matrix. The protein is an essential component of the urea cycle, and functions in ammonium detoxification and biosynthesis of the amino acid arginine. Mutations in this gene result in hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome. There is a pseudogene of this locus on the Y chromosome.

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Data Correlations | 1,309 studies

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Tissues category icon Normal tissues
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Zygote 100 100
Fetal organ 98 98
Thyroid gland 96 96
Duodenum 92 92
Small intestine 90 90
Penis 88 88
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Compounds category icon Compounds
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Formic Aldehyde 100 100
Propiconazole 91 91
Otoline 89 89
Kinetin 89 89
Heptaminol 82 82
Triadimefon 78 78
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Diseases category icon Diseases
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Hyperornithinemia 100 100
Cholangiocarcinoma o… 100 100
Triploidy 91 91
Anomaly of chromosom… 90 90
Hepatitis C 78 78
Neoplasm of liver 71 71
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Individual Studies

  • OMIM - Congenital disorder

    score: 100100 | Homo sapiens Homo sapiens | Mutations/Phenotypic   Mutations/Phenotypic

    This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories.

    Source: NextBio Library/Mutation and Phenotypic data

  • Myclobutanil, propiconazole and triadimefon mid-dose and high-dose effects in rat liver

    score: 9999 | Rattus norvegicus Rattus norvegicus | RNA Expression   RNA Expression

    The modes of triazole reproductive toxicity have been characterized by an observed increased in serum testosterone and reduced insemination and fertility indices. The key events involved in the disruption in testosterone homeostasis and reduced fertility remain unclear. Gene expression analysis was …

    Authors: Dix J David, Goetz K Amber

    Organization: US EPA ORD/NCCT 109 TW Alexander Drive R…
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Associated Researchers

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Thought leaders and organizations working on research involving SLC25A15.

View All Author iconAuthors
  • C Dionisi-Vici
  • José A Camacho
  • F M Santorelli
  • Natalia Rioseco-Camacho
  • María de la Paz Sanchez
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Office of Rare Diseases (ORD)
View All Affiliations icon Organizations
  • National Cancer Center Research Institute
  • Istituto di Ricovero e Cura a Carattere Scientifico Children's Hospita…
  • Centre Hospitalier Universitaire Sainte-Justine
  • Institute of Human Genetics
  • Vanderbilt University Medical Center

Clinical Trials | 1 trial

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