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solute carrier family 1 (glial high affinity glutamate transporter), member 2
This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not kno...
Normal tissues
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|---|---|---|---|
| Substantia nigra |
100
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| Putamen |
99
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| Nucleus accumbens |
94
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| Vestibular nuclear c… |
93
|
||
| Subdivision of nucle… |
93
|
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| Ventral tegmental ar… |
93
|
Compounds
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|
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|---|---|---|---|
| Cephaloridine |
100
|
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| Dimethylnitrosamine |
95
|
||
| 4-aminosalicylic Aci… |
73
|
||
| Diethylnitrosamine |
73
|
||
| Lorazepam |
71
|
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| Epiestriol |
71
|
 Individual Studies |
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|---|---|
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Homo sapiens
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RNA Expression
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No genetic association between the SLC1A2 gene and Japanese patients with schizophrenia.
Authors: Yasuhito Nagai, Tohru Ohnuma, Jun Karibe, Nobuto Shibata, Hitoshi Maeshima, Hajime Baba, Tokiko Hatano, Ryo Hanzawa, Heii Arai
Neuroscience letters 2009 Oct 9 -
The concentrations and distributions of three C-terminal variants of the GLT1 (EAAT2; slc1a2) glutamate transporter protein in rat brain tissue suggest differential regulation.
Authors: S Holmseth, H A Scott, K Real, K P Lehre, T B Leergaard, J G Bjaalie, N C Danbolt
Neuroscience 2009 Sep 15
Thought leaders and organizations working on research involving SLC1A2.
- Michael B Robinson
- Jeffrey D Rothstein
- Svetlana Vidensky
- Carlos Matute
- Bala T S Susarla
- Drexel University
- Johns Hopkins University
- University of Pennsylvania
- University of Montana
- Mount Sinai School of Medicine
- Kagoshima University
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Compassionate Use of Ceftriaxone in Patients With Amyotrophic Lateral Sclerosis (ALS)
conditions: Amyotrophic Lateral Sclerosis ; Cerebrospinal Fluid ; Neurodegenerative Disease ; Motor Neuron Disease
interventions: none
Community
Postdotoral Fellow
University of Calgary
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