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SIL1 homolog, endoplasmic reticulum chaperone (S. cerevisiae)

This gene encodes a resident endoplasmic reticulum (ER), N-linked glycoprotein with an N-terminal ER targeting sequence, 2 putative N-glycosylation sites, and a C-terminal ER retention signal. This protein functions as a nucleotide exchange factor for another unfolded protein response protein. Mutations in this gene have been associated with Marinesco-Sjogren syndrome. Alternate transcriptional splice variants have been characterized. [provided by RefSeq]

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Data Correlations | 1,227 studies

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Tissues category icon Normal tissues
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Vomeronasal organ 100 100
Set of pancreatic is… 96 96
Superior surface of … 86 86
Cecum 85 85
Pericardium 80 80
Great saphenous vein 76 76
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Compounds category icon Compounds
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Ccris 7556 100 100
Dextrose 71 71
Mexiletine 63 63
Fazarabine 60 60
Cilengitide 59 59
Cefoperazone 59 59
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Diseases category icon Diseases
Score Help
Marinesco-Sjogren sy… 100 100
T4 44 44
Dengue shock syndrom… 43 43
Prostatic hyperplasi… 41 41
Dupuytren's disease … 41 41
T1 39 39
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Individual Studies

  • OMIM - Congenital disorder

    score: 100100 | Homo sapiens Homo sapiens | Mutations/Phenotypic   Mutations/Phenotypic

    This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories.

    Source: NextBio Library/Mutation and Phenotypic data
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Associated Researchers

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Thought leaders and organizations working on research involving SIL1.

View All Author iconAuthors
  • C Peter Verrijzer
  • Lisbeth Tranebjaerg
  • Lisette Mohrmann
  • Anna-Kaisa Anttonen
  • Susan L Ackerman
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • National Heart, Lung, and Blood Institute (NHLBI)
View All Affiliations icon Organizations
  • University of Helsinki
  • Universität des Saarlandes
  • Erasmus University Medical Center
  • Jackson Laboratory
  • Aachen University of Technology

Clinical Trials | 1 trial

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Community

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