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sphingosine-1-phosphate phosphatase 1

Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. SGPP1 catalyzes the degradation of S1P via salvage and recycling of sphingosine into long-chain ceramides (Mandala et al., 2000 [PubMed 10859351]; Le Stunff et al., 2007 [PubMed 17895250]).[supplied by OMIM]

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Data Correlations | 1,564 studies

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Diseases category icon Diseases
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Conn syndrome 100 100
Gonorrhea 98 98
Chromosomal anomalie… 93 93
Erythema nodosum lep… 93 93
Grade III acute reje… 91 91
Familial hypercholes… 90 90
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Geneticperturbations category icon Gene perturbations
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CCNA2 gene 100 100
GDNF gene 98 98
PDSS2 gene 94 94
BRAF gene 92 92
IRS1 gene 88 88
Si gene 84 84
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Compounds category icon Compounds
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Troleandomycin 100 100
Zardaverine 88 88
Phthalylsulfathiazol… 87 87
Apazone 81 81
Iodipamide 77 77
Myosmine 77 77
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Individual Studies

  • Effect of tobacco condensate exposure on human bronchial epithelial cells

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    Gene expression patterns were assessed in normal human bronchial epithelial (NHBE) cells exposed to cigarette smoke condensates (CSC) from commercial cigarettes in order to develop a better understanding of the genomic impact of tobacco exposure.

    Authors: Jorgensen ED, Dozmorov I, Frank MB et al.

    Organization: Oklahoma Medical Research Foundation Art…

  • Broad Connectivity Map (CMAP 2.0) compound database

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    A reference collection of genome-wide transcriptional expression data from cultured human cells treated with bioactive small molecules that enable the discovery of functional connections between drugs, genes and diseases through the transitory feature of common gene-expression changes.

    Authors: Lamb J

    Organization: Broad Institute Seven Cambridge Center C…
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Associated Researchers

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Thought leaders and organizations working on research involving SGPP1.

View All Author iconAuthors
  • Paulo Tavares
  • Robert C Burghardt
  • Greg A Johnson
  • Kayla J Bayless
  • Fuller W Bazer
View All Affiliations icon Organizations
  • University of Alabama - Birmingham
  • University of Glasgow
  • University of Connecticut Health Center
  • Mayo Clinic Jacksonville
  • Université Paris VII

Community

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