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selectin P ligand
SELPLG is the high affinity counter-receptor for P-selectin on myeloid cells and stimulated T lymphocytes. As such, it plays a critical role in the tethering of these cells to activated platelets or endothelia expressing P-selectin. The organization of the SELPG gene closely resembles that of CD43 and the human platelet glycoprotein GpIb-alpha both of which have an intron in the 5-prime-noncoding region, a long second exon containing the complete coding region, and TATA-less promoters. [provided by RefSeq]
Normal tissues
|
|
||
|---|---|---|---|
| Mesenteric lymph nod… |
100
|
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| Femur |
93
|
||
| Inferior ganglion of… |
91
|
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| Substantia nigra |
89
|
||
| Vestibular nuclear c… |
87
|
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| Subthalamic nucleus |
85
|
Compounds
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|
||
|---|---|---|---|
| Linalyl Pyrophosphat… |
100
|
||
| Butyric Acid |
89
|
||
| Zinc Sulfate (1:1) |
86
|
||
| Imipramine |
78
|
||
| Desoxycorticosterone |
70
|
||
| Trichostatin A |
68
|
Diseases
|
|
||
|---|---|---|---|
| Scott syndrome |
100
|
||
| Sjogren's syndrome |
84
|
||
| Burn injury |
82
|
||
| Acromegaly |
81
|
||
| Androgen insensitivi… |
79
|
||
| Arthritis |
78
|
 Individual Studies |
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|---|---|
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Homo sapiens
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RNA Expression
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Human P-selectin glycoprotein ligand-1 is a functional receptor for enterovirus 71.
Authors: Yorihiro Nishimura, Masayuki Shimojima, Yoshio Tano, Tatsuo Miyamura, Takaji Wakita, Hiroyuki Shimizu
Nature medicine 2009 Jul -
Interaction of the selectin ligand PSGL-1 with chemokines CCL21 and CCL19 facilitates efficient homing of T cells to secondary lymphoid organs.
Authors: Krystle M Veerman, Michael J Williams, Kenji Uchimura, Mark S Singer, Jasmeen S Merzaban, Silvia Naus, Douglas A Carlow, Philip Owen, Jesús Rivera-Nieves, Steven D Rosen,…
Nature immunology 2007 May
Thought leaders and organizations working on research involving SELPLG.
- Dartmouth-Hitchcock Medical Center
- Y's Therapeutics, Inc.
- McGill University
- Wageningen University
- Hull and East Yorkshire Hospitals NHS Trust
- Oklahoma Medical Research Foundation
- University of British Columbia
- University of Minnesota Medical School
- Mount Sinai School of Medicine
- Center for Hemostasis
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Proof of Principle Trial to Determine if Nutritional Supplement Conjugated Linoleic Acid (CLA) Can Modulate the Lipogenic Pathway in Breast Cancer Tissue
conditions: Breast Cancer
interventions: Conjugated Linoleic Acid (CLA)
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Effect of Dietary Conjugated Linoleic Acid (CLA) on Parathyroid Hormone in Men
conditions: Healthy
interventions: Clarinol CLA
