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succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq]
Normal tissues
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|---|---|---|---|
| Skeletal muscle tiss… |
100
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| Cecum |
89
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| Mesenteric lymph nod… |
84
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| Epidermis |
80
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| Brown adipose tissue |
76
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| Quadriceps femoris |
73
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Compounds
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|---|---|---|---|
| Salicylamide |
100
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| Benzoic Acid |
84
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| Clofibric Acid |
84
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| Methyltestosterone |
80
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| Sulfabenzamide |
77
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| Chlorcyclizine |
73
|
Diseases
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|---|---|---|---|
| Paraganglioma |
100
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| Pheochromocytoma |
99
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| Corneal burn |
99
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| Hepatocellular dyspl… |
96
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| Colitis |
91
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| Post-traumatic stres… |
89
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 Individual Studies |
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Homo sapiens
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Mutations/Phenotypic
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Loss of the SdhB, but Not the SdhA, subunit of complex II triggers reactive oxygen species-dependent hypoxia-inducible factor activation and tumorigenesis.
Authors: Robert D Guzy, Bhumika Sharma, Eric Bell, Navdeep S Chandel, Paul T Schumacker
Molecular and cellular biology 2008 Jan -
Contrasting clinical manifestations of SDHB and VHL associated chromaffin tumours.
Authors: Umasuthan Srirangalingam, Bernard Khoo, Lisa Walker, Fiona MacDonald, Robert H Skelly, Emad George, David Spooner, Linda B Johnston, John P Monson, Ashley B Grossman,…
Endocrine-related cancer 2009 Jun
Thought leaders and organizations working on research involving SDHB.
- University Hospital, Angers
- University of Birmingham
- University of Tsukuba
- Northwestern University
- St Bartholomew's Hospital
- University of Birmingham School of Medicine
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Hereditary Paraganglioma: Evaluation of Screening Methods to Detect Tumors in SDH Positive Carriers
conditions: Paraganglioma ; Pheochromocytoma
interventions: diagnosis methods
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[Articles] An immunohistochemical procedure to detect patients with paraganglioma and phaeochromocytoma with germline SDHB, SDHC, or SDHD gene mutations: a retrospective and prospective analysis
Lancet. - July 29, 2009 -
[Reflection and Reaction] Diagnosing patients with hereditary paraganglial tumours
Lancet. - July 29, 2009
Community
Principal Investigator
Tehran University of Medical Sciences
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