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Description: A selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that acts as an atypical antipsychotic agent. It has been shown to improve both positive and negative symptoms in the treatment of schizophrenia. [PubChem]
Drug Type: Small Molecule; Approved; Investigational
Pharmacology: Risperidone is an atypical antipsychotic medication. It is most often used to treat delusional psychosis (including schizophrenia), but risperidone is also used to treat some forms of bipolar disorder and psychotic depression. It also has shown some success in treating symptoms of Asperger's Syndrome and autism. Risperidone is now the most commonly prescribed antipsychotic medication in the United States.
Mechanism of Action: Blockade of dopaminergic D2 receptors in the limbic system alleviates positive symptoms of schizophrenia such as hallucinations, delusions, and erratic behavior and speech. Blockade of serotonergic 5-HT2 receptors in the mesocortical tract, causes an excess of dopamine and an increase in dopamine transmission, resulting in an increase in dopamine transmission and an elimination of core negative symptoms. Dopamine receptors in the nigrostriatal pathway are not affected by risperidone and extrapyramidal effects are avoided. Like other 5-HT2 antagonists, risperidone also binds at alpha(1)-adrenergic receptors and, to a lesser extent, at histamine H1 and alpha(2)-adrenergic receptors.
Indication: For the treatment of schizophrenia in adults and in adolescents, ages 13 to 17, and for the short-term treatment of manic or mixed episodes of bipolar I disorder in children and adolescents ages 10 to 17.
Half Life: 3 hours
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Data Correlations | 2 studies

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Genes category icon Genes
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HRH1 100 100
ADRB1 100 100
HTR2A 100 100
ADRA1A 100 100
DRD2 100 100
TOP3A 96 96
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Biogroups category icon Biogroups
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Neuroactive Ligand Receptor Interac… 100 100
G-alpha-I Pathway 100 100
Monoamine GPCRs 93 93
Kelch related 91 91
Tudor 91 91
I29 - cytotoxic T-lymphocyte antige… 91 91
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    Organization: Department of Computing Science, Univers…

  • Broad Connectivity Map (CMAP 2.0) compound database

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    Authors: Lamb J

    Organization: Broad Institute Seven Cambridge Center C…
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Associated Researchers

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Thought leaders and organizations working on research involving Risperdal.

View All Author iconAuthors
  • Michael T Klein
  • Carol Smith
  • Benoit H Mulsant
  • Bruce G Pollock
  • Milt Teitler
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
  • Janssen Pharmaceutica N.V., Belgium
  • Vanderbilt University
  • Duke University
  • Massachusetts General Hospital
View All Affiliations icon Organizations
  • Albany Medical College
  • Imperial College
  • University of Illinois at Chicago
  • Cardiff University
  • University of California

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