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Description: A long-acting angiotensin-converting enzyme inhibitor. It is a prodrug that is transformed in the liver to its active metabolite ramiprilat. [PubChem]
Drug Type: Small Molecule; Approved
Pharmacology: Ramipril is an angiotensin-converting enzyme (ACE) inhibitor similar to benazepril, fosinopril, and quinapril. An inactive prodrug, ramipril is converted to ramiprilat in the liver and is used to treat hypertension and heart failure, to reduce proteinuria and renal disease in patients with nephropathies, and to prevent stroke, myocardial infarction, and cardiac death in high-risk patients.
Mechanism of Action: Ramiprilat, the active metabolite, competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II. As angiotensin II is a vasoconstrictor and a negative-feedback mediator for renin activity, lower concentrations result in a decrease in blood pressure and an increase in plasma renin. Ramiprilat may also act on kininase II, an enzyme identical to ACE that degrades the vasodilator bradykinin.
Indication: For diuretics and digitalis in congestive heart failure as adjunctive therapy and for use in prophylaxis in post MI.
Half Life: 2-4 hours
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Data Correlations | 3 studies

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Genes category icon Genes
Score Help
ACE 100 100
CFDP1 98 98
619380 98 98
RCC1 93 93
552889 93 93
TIMM50 91 91
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Biogroups category icon Biogroups
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Proteinase inhibitor I1, Kazal 100 100
IGF-1 Pathway 97 97
Nuclear Receptors 96 96
Zinc finger, nuclear hormone recept… 96 96
Nuclear hormone receptor, ligand-bi… 96 96
Nuclear hormone receptor, ligand-bi… 96 96
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Individual Studies

  • Drug-Induced Renal Tubular Toxicity

    Rattus norvegicus Rattus norvegicus | RNA Expression   RNA Expression

    These data support the publication titled "A Gene Expression Signature that Predicts the Future Onset of Drug-Induced Renal Tubular Toxicity"

    Authors: Fielden MR, Eynon BP, Natsoulis G et al.

    Organization: Iconix Pharmaceuticals 325 E Middlefield…

  • Drug target sets for approved compounds

    Homo sapiens Homo sapiens | Therapeutic   Therapeutic

    The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

    Authors: David S Wishart, Craig Knox, An Chi Guo et al.

    Organization: Department of Computing Science, Univers…
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Associated Researchers

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Thought leaders and organizations working on research involving Ramipril.

View All Author iconAuthors
  • Salim Yusuf
  • Janice Pogue
  • Roland E Schmieder
  • Jackie Bosch
  • J Bosch
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Boehringer Ingelheim Pharmaceuticals
  • Sanofi-Aventis
  • Roxane Laboratories
  • King Pharmaceuticals
  • Teva Pharmaceuticals USA
View All Affiliations icon Organizations
  • McMaster University
  • Gachon Medical School
  • Ludwig Maximilians University Munchen
  • Monash University
  • University of Toronto

Clinical Trials | 108 trials

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