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RAR-related orphan receptor A
The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq]
Normal tissues
|
|
||
|---|---|---|---|
| Set of fingers |
100
|
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| Nipple |
84
|
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| Epidermis |
84
|
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| Penis |
74
|
||
| Adrenal cortex |
71
|
||
| Substantia nigra |
66
|
Compounds
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|
||
|---|---|---|---|
| Dhs Sirna |
100
|
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| Deferoxamine |
92
|
||
| Methylbenzylnitrosam… |
79
|
||
| Tipifarnib |
77
|
||
| Brain Derived Neurot… |
75
|
||
| Fibroblast Growth Fa… |
75
|
 Individual Studies |
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Homo sapiens
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RNA Expression
Mus musculus
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A functional genomics strategy reveals Rora as a component of the mammalian circadian clock.
Authors: Trey K Sato, Satchidananda Panda, Loren J Miraglia, Teresa M Reyes, Radu D Rudic, Peter McNamara, Kinnery A Naik, Garret A FitzGerald, Steve A Kay, John B Hogenesch
Neuron 2004 Aug 19 -
RORA, a large common fragile site gene, is involved in cellular stress response.
Oncogene 2006 May 11
Thought leaders and organizations working on research involving RORA.
- University of Dundee
- Université Pierre et Marie Curie-Paris 6
- Université de Rouen
- Mayo Clinic College of Medicine
- Indiana University School of Medicine
- Neuroscience Institute
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Rosuvastatin in Rheumatoid Arthritis (RORA)
conditions: Rheumatoid Arthritis
interventions: rosuvastatin ; placebo
