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ring finger protein 8
The protein encoded by this gene contains a RING finger motif and a FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq]
Normal tissues
|
|
||
|---|---|---|---|
| Zygote |
100
|
||
| Preoptic area |
93
|
||
| Cardia of stomach |
87
|
||
| Superior vena cava |
83
|
||
| Mucosa of mouth |
82
|
||
| Cecum |
81
|
Compounds
|
|
||
|---|---|---|---|
| Salsolidin |
100
|
||
| Sulindac |
95
|
||
| Atenolol |
94
|
||
| Lidocaine |
91
|
||
| Dimethadione |
88
|
||
| Butoconazole |
88
|
Diseases
|
|
||
|---|---|---|---|
| Heat exposure |
100
|
||
| Starvation |
96
|
||
| Carcinoid tumor (exc… |
91
|
||
| Cardiac arrhythmia |
87
|
||
| Cardiac transplant r… |
81
|
||
| Aging |
81
|
 Individual Studies |
|
|---|---|
|
|
Rattus norvegicus
|
RNA Expression
Homo sapiens
|
-
RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins.
Authors: Niels Mailand, Simon Bekker-Jensen, Helene Faustrup, Fredrik Melander, Jiri Bartek, Claudia Lukas, Jiri Lukas
Cell 2007 Nov 30 -
RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly.
Authors: Michael S Y Huen, Robert Grant, Isaac Manke, Kay Minn, Xiaochun Yu, Michael B Yaffe, Junjie Chen
Cell 2007 Nov 30
Thought leaders and organizations working on research involving RNF8.
- Yale University School of Medicine
- Institute of Cancer Biology and Centre for Genotoxic Stress Research
- University of Birmingham
- University of Toronto
- University of Michigan Medical School
