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ring finger protein 128

The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq]

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Data Correlations | 1,121 studies

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Tissues category icon Normal tissues
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Cecum 100 100
Duodenum 89 89
Vomeronasal or… 87 87
Olfactory epit… 78 78
Mesenteric lym… 76 76
Blastocyst 74 74
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Compounds category icon Compounds
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Conjugated Lin… 100 100
Lbh-589 66 66
Suberanilohydr… 58 58
Metribolone 54 54
Methylscopolam… 52 52
Alginate 47 47
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Diseases category icon Diseases
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Chronic inters… 100 100
Metastasis fro… 95 95
Oncocytoma of … 94 94
Dedifferentiat… 94 94
N1 90 90
Ovary Cancer 89 89
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Individual Studies

  • Delipidation of white adipose tissue of mice fed conjugated linoleic acid

    score: 100100 | Mus musculus Mus musculus | RNA Expression   RNA Expression

    he white adipose tissue (WAT) rapidly loses mass when mice are fed a diet containing trans-10, cis-12 conjugated linoleic acid (t10c12 CLA). A microarray analysis of WAT due to CLA feeding was performed to better define the processes and genes involved.

    Authors: LaRosa CP, Miner J, Xia Y et al.

    Organization: University of Nebraska, Lincoln Center o…

  • Carcinoma Associated Fibroblast Like Differentiation of Human Mesenchymal Stem Cells

    score: 9999 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    Carcinoma associated fibroblasts (CAFs) have recently been implicated in important aspects of epithelial solid tumor biology. In this study we demonstrate that human bone marrow-derived mesenchymal stem cells (hMSCs) exposed to tumor-conditioned medium (TCM) over a prolonged period of time assume a …

    Authors: Mishra J Pravin, Mishra J Prasun, Humeniuk Rita et al.

    Organization: UMDNJ Pharmacology Bertino/Banerjee 195 …
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Associated Researchers

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Thought leaders and organizations working on research involving RNF128.

View All Author iconAuthors
  • C Garrison Fathman
  • Christine M Seroogy
  • Luis Soares
  • Leon Su
  • Jack T Lin
View All Affiliations icon Organizations
  • Stanford University School of Medicine
  • University of Wisconsin
  • Stanford University
  • Kobe University Graduate School of Medicine
  • University of Toronto

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