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regulator of G-protein signaling 5

The regulator of G protein signaling (RGS) proteins are signal transduction molecules that have structural homology to SST2 of Saccharomyces cerevisiae and EGL-10 of Caenorhabditis elegans. Multiple genes homologous to SST2 are present in higher eukaryotes. RGS proteins are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators.[supplied by OMIM]

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Data Correlations | 1,463 studies

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Tissues category icon Normal tissues
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Aorta 100 100
Pylorus 99 99
Cardia of stomach 94 94
Fundus of stomach 93 93
Myometrium 91 91
Urethra 90 90
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Compounds category icon Compounds
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Paclitaxel (jan/usp) 100 100
Puy 87 87
Angiotensin 84 84
Motexafin Gadolinium 80 80
Carbon-14c Dioxide 78 78
Nac 78 78
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Diseases category icon Diseases
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Metastasis from mali… 100 100
Abdominal aortic ane… 98 98
Clear cell carcinoma… 93 93
Streptococcal pneumo… 91 91
Fetal malnutrition 90 90
Knee osteoarthritis 85 85
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Individual Studies

  • Hs294T cells treated with elesclomol in combination with paclitaxel or NAC

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    We used microarrays to detail gene expression changes in Hs 294T human melanoma cells after treatment with elesclomol alone, or in combination with paclitaxel, to aide in identifing the mechnism of action of elesclomol.

    Organization: Synta Pharmaceuticals Corp. Biology 45 H…
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Associated Researchers

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Thought leaders and organizations working on research involving RGS5.

View All Author iconAuthors
  • Ruth Ganss
  • Mitali Manzur
  • Michael T Greenwood
  • Zhao Yang
  • William M Mahoney
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • National Heart, Lung, and Blood Institute (NHLBI)
View All Affiliations icon Organizations
  • University of Western Australia Centre for Medical Research
  • McGill University
  • Academic Medical Center
  • University of Washington
  • Chiba University Graduate School of Medicine

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