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RAD18 homolog (S. cerevisiae)
The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. [provided by RefSeq]
Normal tissues
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|
||
|---|---|---|---|
| Zygote |
100
|
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| Femur |
79
|
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| Penis |
75
|
||
| Substantia nigra par… |
74
|
||
| Superior surface of … |
73
|
||
| Pericardium |
73
|
Compounds
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|
||
|---|---|---|---|
| Nickel [nickel And N… |
100
|
||
| Irinotecan |
91
|
||
| Gp120 |
88
|
||
| Iron Nitrilotriaceta… |
85
|
||
| Phenylephrine |
85
|
||
| 4-hydroxytamoxifen |
82
|
 Individual Studies |
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|---|---|
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Mus musculus
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RNA Expression
Homo sapiens
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RAD6-RAD18-RAD5-pathway-dependent tolerance to chronic low-dose ultraviolet light.
Authors: Takashi Hishida, Yoshino Kubota, Antony M Carr, Hiroshi Iwasaki
Nature 2009 Jan 29 -
RAD18 transmits DNA damage signalling to elicit homologous recombination repair.
Authors: Jun Huang, Michael S Y Huen, Hongtae Kim, Charles Chung Yun Leung, J N Mark Glover, Xiaochun Yu, Junjie Chen
Nature cell biology 2009 May
Thought leaders and organizations working on research involving RAD18.
- Kumamoto University
- Imperial College London
- Tohoku University
- Medical Research Council Laboratory of Molecular Biology
- University Medical Center
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E.V.O.L.V.E. Trial™: EValuation Of Cinacalcet HCl Therapy to Lower CardioVascular Events
conditions: Secondary Hyperparathyroidism ; Chronic Kidney Disease
interventions: Cinacalcet ; Sensipar (Cinacalcet HCl) ; Placebo
