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Description: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2. [PubChem]
Drug Type: Small Molecule; Approved
Pharmacology: Quinacrine has been used as an antimalarial drug and as an antibiotic. It is used to treat giardiasis, a protozoal infection of the intestinal tract, and certain types of lupus erythematosus, an inflammatory disease that affects the joints, tendons, and other connective tissues and organs. Quinacrine may be injected into the space surrounding the lungs to prevent reoccurrence of pneumothorax. The exact way in which quinacrine works is unknown. It appears to interfere with the parasite's metabolism.
Mechanism of Action: The exact mechanism of antiparasitic action is unknown; however, quinacrine binds to deoxyribonucleic acid (DNA) in vitro by intercalation between adjacent base pairs, inhibiting transcription and translation to ribonucleic acid (RNA). Quinacrine does not appear to localize to the nucleus of Giaridia trophozoites, suggesting that DNA binding may not be the primary mechanism of its antimicrobial action. Fluorescence studies using Giardia suggest that the outer membranes may be involved. Quinacrine inhibits succinate oxidation and interferes with electron transport. In addition, by binding to nucleoproteins, quinacrine suppress the lupus erythematous cell factor and acts as a strong inhibitor of cholinesterase.
Indication: For the treatment of giardiasis and cutaneous leishmaniasis and the management of malignant effusions.
Half Life: 5 to 14 days
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Data Correlations | 1 study

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Genes category icon Genes
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MYC 100 100
GPR87 96 96
PUS7 95 95
SLC19A1 94 94
PDCD11 92 92
FAS 88 88
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Biogroups category icon Biogroups
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RNA-directed DNA polymerase (revers… 100 100
Ricin B-related lectin 98 98
Phenylpropanoid Biosynthesis 96 96
RNA helicase, DEAD-box type, Q moti… 94 94
RNA Polymerase Pathway 94 94
ATP Synthesis 94 94
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Individual Studies

  • Broad Connectivity Map (CMAP 2.0) compound database

    Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    A reference collection of genome-wide transcriptional expression data from cultured human cells treated with bioactive small molecules that enable the discovery of functional connections between drugs, genes and diseases through the transitory feature of common gene-expression changes.

    Authors: Lamb J

    Organization: Broad Institute Seven Cambridge Center C…
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Associated Researchers

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Thought leaders and organizations working on research involving Quinacrine.

View All Author iconAuthors
  • David Hubacher
  • Wei-Yi Ong
  • Stéphane Bach
  • Curtis A Parvin
  • Suvankar Pal
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Cleveland BioLabs
  • Medical Research Council
  • National Institute on Aging (NIA)
  • National Institute of Neurology and Neurosurgery, Mexico
  • Washington University School of Medicine
View All Affiliations icon Organizations
  • Washington University School of Medicine
  • National University of Singapore
  • University of Illinois at Urbana-Champaign
  • Institut Pasteur
  • Federal University of Minas Gerais

Clinical Trials | 9 trials

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