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protein tyrosine phosphatase, receptor type, M

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another m...

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Data Correlations | 1,472 studies

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Tissues category icon Normal tissues
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Thyroid gland 100 100
Caudate nucleu… 95 95
Thalamus 94 94
Synovial membr… 92 92
Pericardium 92 92
Zone of stomac… 89 89
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Compounds category icon Compounds
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[bleocin(tm) 3… 100 100
Bicuculline 88 88
Mustard Gas 86 86
Polyamide Ii 86 86
Topotecan Lact… 83 83
Androstanolone 81 81
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Diseases category icon Diseases
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Sedentary 100 100
Streptococcal … 88 88
Exercise 87 87
Acquired absen… 85 85
Human immunode… 83 83
SAIDS 82 82
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Individual Studies

  • Low and High Capacity Runner Rats - Sedentary and Trained

    score: 100100 | Rattus norvegicus Rattus norvegicus | RNA Expression   RNA Expression

    Aerobic capacity is a strong predictor of cardiovascular mortality. To determine the relationship between aerobic capacity and cardiac gene expression we examined genome-wide gene expression in hearts of rats artificially selected for high- and low running capacity (HCR and LCR, respectively) over 1…

    Authors: Bye A, Langaas M, Hoydal MA et al.

    Organization: NTNU Olav Kyrres gt 9 TRONDHEIM 7489 Cou…

  • Genetically diverse strains of mice infected with Streptococcus zooepidemicus

    score: 9999 | Mus musculus Mus musculus | RNA Expression   RNA Expression

    To evaluate the effect of genetic background on the immune response to streptococcal infection, eight genetically diverse strains of mice (129/SvImJ, A/J, Balb/cJ, C3H/HeJ, C57BL/6J, Cast/EI, DBA/2J, and FVB/NJ) were infected with Streptococcus zooepidemicus by orapharyngeal aspiration.

    Source: NextBio Library/Immune response and infection
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Associated Researchers

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Thought leaders and organizations working on research involving PTPRM.

View All Author iconAuthors
  • Susann M Brady-Kalnay
  • Susan M Burden-Gulley
  • W H Moolenaar
  • Martijn F B G Gebbink
  • Robert H Miller
View All Affiliations icon Organizations
  • Case Western Reserve University
  • University of Oxford
  • Pennsylvania State University College of Medicine
  • Netherlands Cancer Institute
  • Institute of Biochemistry

Community

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