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protein tyrosine phosphatase, receptor type, C

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with componen...

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Data Correlations | 1,376 studies

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Tissues category icon Normal tissues
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Mesenteric lymph nod… 100 100
Femur 77 77
Thymus 72 72
Bronchus 68 68
Nongranular leukocyt… 67 67
Superior surface of … 67 67
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Compounds category icon Compounds
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Methylnitronitrosogu… 100 100
Chlorthalidone 98 98
Naphthalene 89 89
Daboiatoxin 88 88
Ceftazidime 86 86
Amodiaquine, Flavoqu… 86 86
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Diseases category icon Diseases
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Multiple sclerosis 100 100
Hepatitis C 100 100
Systemic lupus eryth… 99 99
Severe combined immu… 99 99
Multiple benign mela… 99 99
Mycosis fungoides 97 97
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Individual Studies

  • OMIM - Disease caused by virus

    score: 100100 | Homo sapiens Homo sapiens | Mutations/Phenotypic   Mutations/Phenotypic

    This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories.

    Source: NextBio Library/Mutation and Phenotypic data
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Associated Researchers

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Thought leaders and organizations working on research involving PTPRC.

View All Author iconAuthors
  • Arthur Weiss
  • Michelle L Hermiston
  • E Tchilian
  • Peter C L Beverley
  • Mikael Sigvardsson
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Fred Hutchinson Cancer Research Center
  • Baylor College of Medicine
  • Tehran University of Medical Sciences
  • The University of North Carolina, Chapel Hill
  • Washington University School of Medicine
View All Affiliations icon Organizations
  • University of California
  • University of California, San Francisco
  • University of Oxford
  • Edward Jenner Institute for Vaccine Research
  • Burnham Institute for Medical Research

Clinical Trials | 26 trials

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Community

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