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protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of...

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Data Correlations | 1,781 studies

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Tissues category icon Normal tissues
Score Help
Preoptic area 100 100
Substantia nigra 100 100
Cecum 92 92
Trigeminal ganglion 89 89
Cardia of stomach 81 81
Epidermis 80 80
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Compounds category icon Compounds
Score Help
Oleandomycin 100 100
Metolazone 93 93
Clozapine 88 88
Phthalylsulfathiazol… 87 87
Quide 85 85
Quipazine 76 76
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Diseases category icon Diseases
Score Help
Myxoma 100 100
Atrial myxoma with l… 100 100
Papillary thyroid ca… 99 99
Tumor of adrenal cor… 99 99
Facioscapulohumeral … 59 59
Starvation 54 54
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Individual Studies

  • Mouse Phenotypes - Lentigo

    score: 100100 | Mus musculus Mus musculus | Mutations/Phenotypic   Mutations/Phenotypic

    This study contains curated mouse gene mutation data extracted from the Mouse Genome Database (MGD) at The Jackson Laboratory, Bar Harbor, Maine. Additional computational processing and curation of mouse phenotype data was performed to further organize and group data from related phenotypes into uni…

    Source: NextBio Library/Mutation and Phenotypic data

  • Cancer census - gene mutations in cancer and other diseases

    score: 100100 | Homo sapiens Homo sapiens | Mutations/Phenotypic   Mutations/Phenotypic

    The Cancer Gene Census is an ongoing effort to catalogue those genes for which mutations have been causally implicated in cancer. The original census and analysis was published in Nature Reviews Cancer

    Authors: P Andrew Futreal, Lachlan Coin, Mhairi Marshall et al.

    Organization: Cancer Genome Project, Human Genome Anal…
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Associated Researchers

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Thought leaders and organizations working on research involving PRKAR1A.

View All Author iconAuthors
  • Constantine A Stratakis
  • Lawrence S Kirschner
  • Ioannis Bossis
  • Maria Nesterova
  • Jérôme Bertherat
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Assistance Publique - Hôpitaux de Paris
View All Affiliations icon Organizations
  • National Institute of Child Health and Human Development
  • Ohio State University
  • Baylor College of Medicine
  • Institute of Haematology
  • University of Basel

Clinical Trials | 1 trial

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Community

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