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peroxiredoxin 1
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq]
Normal tissues
|
|
||
|---|---|---|---|
| Cecum |
100
|
||
| Cardia of stomach |
96
|
||
| Thyroid gland |
93
|
||
| Mucosa of pharynx |
88
|
||
| Duodenum |
86
|
||
| Vermis of cerebellum |
83
|
Compounds
|
|
||
|---|---|---|---|
| Cumolhydroperoxide |
100
|
||
| Levocarnitine |
94
|
||
| Nsc151063 |
72
|
||
| W01300000 |
70
|
||
| Bactopeptone |
70
|
||
| Phorbol Ester |
69
|
Diseases
|
|
||
|---|---|---|---|
| Corneal burn |
100
|
||
| SAIDS |
92
|
||
| Human immunodeficien… |
88
|
||
| Impaired glucose tol… |
86
|
||
| Light chain myeloma |
86
|
||
| Hodgkin disease, nod… |
86
|
 Individual Studies |
|
|---|---|
|
|
Saccharomyces cerevisiae
|
RNA Expression
-
The antioxidant enzyme Prdx1 controls neuronal differentiation by thiol-redox-dependent activation of GDE2.
Authors: Ye Yan, Priyanka Sabharwal, Meenakshi Rao, Shanthini Sockanathan
Cell 2009 Sep 18 -
Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression.
Authors: Carola A Neumann, Daniela S Krause, Christopher V Carman, Shampa Das, Devendra P Dubey, Jennifer L Abraham, Roderick T Bronson, Yuko Fujiwara, Stuart H Orkin, Richard A Van Etten
Nature 2003 Jul 31
Thought leaders and organizations working on research involving PRDX1.
- Ewha Womans University
- Harvard Medical School
- Roswell Park Cancer Institute
- University of Texas M.D. Anderson Cancer Center
- University of Virginia
