PPARG - NextBio

- Overview
- Gene Details
RESEARCH
- Data Correlations
PUBLICATIONS
NEXTBIO COMMUNITY
- Users
- Groups

Search Term: PPARG (gene)

Overview

peroxisome proliferator-activated receptor gamma

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [prov...

View Gene Details

Data Correlations | 1,210 studies

View All

Normal tissues

Score

Adipose tissue

100

Cecum

Synovial membrane

Pericardium

Vulva

Subdivision of nucle…

View Top Normal tissues

Compounds

Score

Troglitazone

100

Pioglitazone

100

Rosiglitazone

100

Tomatidine

Flexamine G

Azt & Li & Epo

View Top Compounds

Diseases

Score

Familial generalized…

100

Insulin-resistant di…

100

Familial partial lip…

100

Metabolic syndrome X

Insulin resistance

Follicular thyroid c…

View Top Diseases

Individual Studies
Mouse Phenotypes - Congenital connective tissue disorder score: 100 \| Mus musculus \| Mutations/Phenotypic This study contains curated mouse gene mutation data extracted from the Mouse Genome Database (MGD) at The Jackson Laboratory, Bar Harbor, Maine. Additional computational processing and curation of mouse phenotype data was performed to further organize and group data from related phenotypes into uni… Source: NextBio Library/Mutation and Phenotypic data	Cancer census - gene mutations in cancer and other diseases score: 100 \| Homo sapiens \| Mutations/Phenotypic The Cancer Gene Census is an ongoing effort to catalogue those genes for which mutations have been causally implicated in cancer. The original census and analysis was published in Nature Reviews Cancer Authors: P Andrew Futreal, Lachlan Coin, Mhairi Marshall et al. Organization: Cancer Genome Project, Human Genome Anal…

Individual Studies

Mouse Phenotypes - Congenital connective tissue disorder

score: 100 | Mus musculus | Mutations/Phenotypic

This study contains curated mouse gene mutation data extracted from the Mouse Genome Database (MGD) at The Jackson Laboratory, Bar Harbor, Maine. Additional computational processing and curation of mouse phenotype data was performed to further organize and group data from related phenotypes into uni…

Source: NextBio Library/Mutation and Phenotypic data

Cancer census - gene mutations in cancer and other diseases

score: 100 | Homo sapiens | Mutations/Phenotypic

The Cancer Gene Census is an ongoing effort to catalogue those genes for which mutations have been causally implicated in cancer. The original census and analysis was published in Nature Reviews Cancer

Authors: P Andrew Futreal, Lachlan Coin, Mhairi Marshall et al.

Organization: Cancer Genome Project, Human Genome Anal…